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Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach

BACKGROUND: Apolipoprotein E (APOE) gene is a ligand protein in humans which mediates the metabolism of cholesterol by binding to the low-density lipoprotein receptor (LDLR). P.Leu167del mutation in APOE gene was recently connected with Familial Hypercholesterolemia, a condition associated with prem...

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Detalles Bibliográficos
Autores principales:	Rashidi, Omran Mohammed, H.Nazar, Fatima Amanullah, Alama, Mohamed Nabil, Awan, Zuhier Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688386/ https://www.ncbi.nlm.nih.gov/pubmed/29204218 http://dx.doi.org/10.2174/1874192401711010084

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