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Glycan Phosphorylases in Multi-Enzyme Synthetic Processes

Glycoside phosphorylases catalyse the reversible synthesis of glycosidic bonds by glyco-sylation with concomitant release of inorganic phosphate. The equilibrium position of such reactions can render them of limited synthetic utility, unless coupled with a secondary enzymatic step where the reaction...

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Detalles Bibliográficos
Autores principales: Pergolizzi, Giulia, Kuhaudomlarp, Sakonwan, Kalita, Eeshan, Field, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688430/
https://www.ncbi.nlm.nih.gov/pubmed/28799504
http://dx.doi.org/10.2174/0929866524666170811125109
Descripción
Sumario:Glycoside phosphorylases catalyse the reversible synthesis of glycosidic bonds by glyco-sylation with concomitant release of inorganic phosphate. The equilibrium position of such reactions can render them of limited synthetic utility, unless coupled with a secondary enzymatic step where the reaction lies heavily in favour of product. This article surveys recent works on the combined use of glycan phosphorylases with other enzymes to achieve synthetically useful processes.