Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection

BACKGROUND: The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from CXCR4 (X4)-tropic HIV-1 infection, making CXCR4 an important target for HIV-1...

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Detalles Bibliográficos
Autores principales: Wang, Qiankun, Chen, Shuliang, Xiao, Qiaoqiao, Liu, Zhepeng, Liu, Shuai, Hou, Panpan, Zhou, Li, Hou, Wei, Ho, Wenzhe, Li, Chunmei, Wu, Li, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688617/
https://www.ncbi.nlm.nih.gov/pubmed/29141633
http://dx.doi.org/10.1186/s12977-017-0375-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688617/
https://www.ncbi.nlm.nih.gov/pubmed/29141633
http://dx.doi.org/10.1186/s12977-017-0375-0

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