Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

BACKGROUND: The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Polygenic risk scores (PRS) ma...

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Detalles Bibliográficos
Autores principales: Ibanez, Laura, Dube, Umber, Saef, Benjamin, Budde, John, Black, Kathleen, Medvedeva, Alexandra, Del-Aguila, Jorge L., Davis, Albert A., Perlmutter, Joel S., Harari, Oscar, Benitez, Bruno A., Cruchaga, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688622/
https://www.ncbi.nlm.nih.gov/pubmed/29141588
http://dx.doi.org/10.1186/s12883-017-0978-z

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