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Clozapine-induced Acute Hypertriglyceridemia
The aim of this study is to highlight the association between the use of clozapine and the early development of hypertriglyceridemia, a condition that substantially increases the risk of cardiovascular events and other medical complications. A 34-year-old female with a background history of schizoph...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688901/ https://www.ncbi.nlm.nih.gov/pubmed/29200570 http://dx.doi.org/10.4103/0253-7176.217031 |
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author | Kumar, Mitesh Sidana, Ajeet |
author_facet | Kumar, Mitesh Sidana, Ajeet |
author_sort | Kumar, Mitesh |
collection | PubMed |
description | The aim of this study is to highlight the association between the use of clozapine and the early development of hypertriglyceridemia, a condition that substantially increases the risk of cardiovascular events and other medical complications. A 34-year-old female with a background history of schizophrenia presented with acute elevation of serum triglycerides and cholesterol within 2 weeks of starting clozapine. Her metabolic parameters normalized following discontinuation of clozapine. Possible hypotheses for lipid dysregulation with atypical antipsychotics include weight gain, dietary changes, and development of glucose intolerance; however, some other factors may be responsible for this rapid escalation of lipid levels. Lipid and metabolic profiles should be closely monitored in patients receiving clozapine to facilitate early detection and intervention to prevent further health complications. |
format | Online Article Text |
id | pubmed-5688901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56889012017-12-01 Clozapine-induced Acute Hypertriglyceridemia Kumar, Mitesh Sidana, Ajeet Indian J Psychol Med Case Report The aim of this study is to highlight the association between the use of clozapine and the early development of hypertriglyceridemia, a condition that substantially increases the risk of cardiovascular events and other medical complications. A 34-year-old female with a background history of schizophrenia presented with acute elevation of serum triglycerides and cholesterol within 2 weeks of starting clozapine. Her metabolic parameters normalized following discontinuation of clozapine. Possible hypotheses for lipid dysregulation with atypical antipsychotics include weight gain, dietary changes, and development of glucose intolerance; however, some other factors may be responsible for this rapid escalation of lipid levels. Lipid and metabolic profiles should be closely monitored in patients receiving clozapine to facilitate early detection and intervention to prevent further health complications. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5688901/ /pubmed/29200570 http://dx.doi.org/10.4103/0253-7176.217031 Text en Copyright: © 2017 Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Kumar, Mitesh Sidana, Ajeet Clozapine-induced Acute Hypertriglyceridemia |
title | Clozapine-induced Acute Hypertriglyceridemia |
title_full | Clozapine-induced Acute Hypertriglyceridemia |
title_fullStr | Clozapine-induced Acute Hypertriglyceridemia |
title_full_unstemmed | Clozapine-induced Acute Hypertriglyceridemia |
title_short | Clozapine-induced Acute Hypertriglyceridemia |
title_sort | clozapine-induced acute hypertriglyceridemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688901/ https://www.ncbi.nlm.nih.gov/pubmed/29200570 http://dx.doi.org/10.4103/0253-7176.217031 |
work_keys_str_mv | AT kumarmitesh clozapineinducedacutehypertriglyceridemia AT sidanaajeet clozapineinducedacutehypertriglyceridemia |