A Case of Carbamazepine-induced Severe Cholestatic Hepatitis: Case Report and Review of Literature

Carbamazepine (CBZ) is one of the widely prescribed drugs in the field of neuropsychiatry. We report a case of a 27-year-old female patient presenting with severe cholestatic hepatitis presenting after the initiation of CBZ. We establish the probability of drug-induced liver injury using Council for...

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Detalles Bibliográficos
Autores principales: Ganesh, Suhas, Shukla, Lekhansh, Kandasamy, Arun, Benegal, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688903/
https://www.ncbi.nlm.nih.gov/pubmed/29200572
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_19_17
Descripción
Sumario:Carbamazepine (CBZ) is one of the widely prescribed drugs in the field of neuropsychiatry. We report a case of a 27-year-old female patient presenting with severe cholestatic hepatitis presenting after the initiation of CBZ. We establish the probability of drug-induced liver injury using Council for International Organizations of Medical Sciences/Roussel Uclaf Causality Assessment Method causality assessment scale, and the patient had high probability with a score of 9. We briefly review the literature in this field discussing the scope of the problem, etiopathogenesis, clinical manifestation, course, and management.

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