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Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychoti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688904/ https://www.ncbi.nlm.nih.gov/pubmed/29200573 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17 |
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author | Taylor, S. Trevor Chhabra, Harleen Sreeraj, Vanteemar S. Shivakumar, Venkataram Kalmady, Sunil V. Venkatasubramanian, Ganesan |
author_facet | Taylor, S. Trevor Chhabra, Harleen Sreeraj, Vanteemar S. Shivakumar, Venkataram Kalmady, Sunil V. Venkatasubramanian, Ganesan |
author_sort | Taylor, S. Trevor |
collection | PubMed |
description | Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects. In recent years, functional near-infrared spectroscopy (fNIRS) has been used successfully to study tDCS-induced neuroplastic changes. In a double-blind, sham-controlled design, we applied fNIRS to measure task-dependent cerebral blood flow (CBF) changes as a surrogate outcome of single session tDCS-induced effects on neuroplasticity in a schizophrenia patient with persistent auditory hallucinations. The observations are discussed in this case report. |
format | Online Article Text |
id | pubmed-5688904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56889042017-12-01 Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy Taylor, S. Trevor Chhabra, Harleen Sreeraj, Vanteemar S. Shivakumar, Venkataram Kalmady, Sunil V. Venkatasubramanian, Ganesan Indian J Psychol Med Case Report Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects. In recent years, functional near-infrared spectroscopy (fNIRS) has been used successfully to study tDCS-induced neuroplastic changes. In a double-blind, sham-controlled design, we applied fNIRS to measure task-dependent cerebral blood flow (CBF) changes as a surrogate outcome of single session tDCS-induced effects on neuroplasticity in a schizophrenia patient with persistent auditory hallucinations. The observations are discussed in this case report. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5688904/ /pubmed/29200573 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17 Text en Copyright: © 2017 Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Taylor, S. Trevor Chhabra, Harleen Sreeraj, Vanteemar S. Shivakumar, Venkataram Kalmady, Sunil V. Venkatasubramanian, Ganesan Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title | Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title_full | Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title_fullStr | Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title_full_unstemmed | Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title_short | Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy |
title_sort | neural effects of transcranial direct current stimulation in schizophrenia: a case study using functional near-infrared spectroscopy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688904/ https://www.ncbi.nlm.nih.gov/pubmed/29200573 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17 |
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