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Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy

Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychoti...

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Autores principales: Taylor, S. Trevor, Chhabra, Harleen, Sreeraj, Vanteemar S., Shivakumar, Venkataram, Kalmady, Sunil V., Venkatasubramanian, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688904/
https://www.ncbi.nlm.nih.gov/pubmed/29200573
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17
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author Taylor, S. Trevor
Chhabra, Harleen
Sreeraj, Vanteemar S.
Shivakumar, Venkataram
Kalmady, Sunil V.
Venkatasubramanian, Ganesan
author_facet Taylor, S. Trevor
Chhabra, Harleen
Sreeraj, Vanteemar S.
Shivakumar, Venkataram
Kalmady, Sunil V.
Venkatasubramanian, Ganesan
author_sort Taylor, S. Trevor
collection PubMed
description Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects. In recent years, functional near-infrared spectroscopy (fNIRS) has been used successfully to study tDCS-induced neuroplastic changes. In a double-blind, sham-controlled design, we applied fNIRS to measure task-dependent cerebral blood flow (CBF) changes as a surrogate outcome of single session tDCS-induced effects on neuroplasticity in a schizophrenia patient with persistent auditory hallucinations. The observations are discussed in this case report.
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spelling pubmed-56889042017-12-01 Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy Taylor, S. Trevor Chhabra, Harleen Sreeraj, Vanteemar S. Shivakumar, Venkataram Kalmady, Sunil V. Venkatasubramanian, Ganesan Indian J Psychol Med Case Report Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%–80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%–30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects. In recent years, functional near-infrared spectroscopy (fNIRS) has been used successfully to study tDCS-induced neuroplastic changes. In a double-blind, sham-controlled design, we applied fNIRS to measure task-dependent cerebral blood flow (CBF) changes as a surrogate outcome of single session tDCS-induced effects on neuroplasticity in a schizophrenia patient with persistent auditory hallucinations. The observations are discussed in this case report. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5688904/ /pubmed/29200573 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17 Text en Copyright: © 2017 Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Taylor, S. Trevor
Chhabra, Harleen
Sreeraj, Vanteemar S.
Shivakumar, Venkataram
Kalmady, Sunil V.
Venkatasubramanian, Ganesan
Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title_full Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title_fullStr Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title_full_unstemmed Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title_short Neural Effects of Transcranial Direct Current Stimulation in Schizophrenia: A Case Study using Functional Near-infrared Spectroscopy
title_sort neural effects of transcranial direct current stimulation in schizophrenia: a case study using functional near-infrared spectroscopy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688904/
https://www.ncbi.nlm.nih.gov/pubmed/29200573
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_238_17
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