Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer

Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and se...

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Detalles Bibliográficos
Autores principales: Zang, Hongjing, Peng, Jianlun, Wang, Weiyuan, Fan, Songqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688939/
https://www.ncbi.nlm.nih.gov/pubmed/29151973
http://dx.doi.org/10.7150/jca.21267
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author Zang, Hongjing
Peng, Jianlun
Wang, Weiyuan
Fan, Songqing
author_facet Zang, Hongjing
Peng, Jianlun
Wang, Weiyuan
Fan, Songqing
author_sort Zang, Hongjing
collection PubMed
description Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and sensitive NSCLC cells. Researches regarding microRNAs and their targets, in platinum drug resistant cases, illuminate novel ideals for platinum-based chemotherapy for NSCLC patients. Therefore, in this review we will focus on three aspects: Epithelial-mesenchymal transition (EMT), cell proliferation and apoptosis, and the roles of microRNAs in cisplatin (CDDP) and carboplatin (CBP) resistance.
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spelling pubmed-56889392017-11-18 Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer Zang, Hongjing Peng, Jianlun Wang, Weiyuan Fan, Songqing J Cancer Review Platinum-based adjuvant chemotherapy improves survival among patients with lung tumors, in particular non-small cell lung cancer (NSCLC). But the predicament of drug resistance in NSCLC patients is frustrating us. The profiles of microRNAs are different between platinum chemotherapy resistant and sensitive NSCLC cells. Researches regarding microRNAs and their targets, in platinum drug resistant cases, illuminate novel ideals for platinum-based chemotherapy for NSCLC patients. Therefore, in this review we will focus on three aspects: Epithelial-mesenchymal transition (EMT), cell proliferation and apoptosis, and the roles of microRNAs in cisplatin (CDDP) and carboplatin (CBP) resistance. Ivyspring International Publisher 2017-10-17 /pmc/articles/PMC5688939/ /pubmed/29151973 http://dx.doi.org/10.7150/jca.21267 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zang, Hongjing
Peng, Jianlun
Wang, Weiyuan
Fan, Songqing
Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title_full Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title_fullStr Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title_full_unstemmed Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title_short Roles of microRNAs in the resistance to platinum based chemotherapy in the non-small cell lung cancer
title_sort roles of micrornas in the resistance to platinum based chemotherapy in the non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688939/
https://www.ncbi.nlm.nih.gov/pubmed/29151973
http://dx.doi.org/10.7150/jca.21267
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AT wangweiyuan rolesofmicrornasintheresistancetoplatinumbasedchemotherapyinthenonsmallcelllungcancer
AT fansongqing rolesofmicrornasintheresistancetoplatinumbasedchemotherapyinthenonsmallcelllungcancer

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