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Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing

The RNA helicase Prp2 facilitates the remodeling of the spliceosomal B(act) complex to the catalytically activated B* complex just before step one of splicing. As a high-resolution cryo-EM structure of the B* complex is currently lacking, the precise spliceosome remodeling events mediated by Prp2 re...

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Detalles Bibliográficos
Autores principales:	Bao, Penghui, Höbartner, Claudia, Hartmuth, Klaus, Lührmann, Reinhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688998/ https://www.ncbi.nlm.nih.gov/pubmed/28864812 http://dx.doi.org/10.1261/rna.063115.117

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