Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage

The insulin-induced gene 1 protein (Insig1) inhibits the cholesterol biosynthesis pathway by retaining transcription factor SREBP in the endoplasmic reticulum, and by causing the degradation of HMGCR, the rate-limiting enzyme in cholesterol biosynthesis. Liver-specific microRNA miR-122, on the other...

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Detalles Bibliográficos
Autores principales: Norman, Kara L., Chen, Tzu-Chun, Zeiner, Gusti, Sarnow, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689008/
https://www.ncbi.nlm.nih.gov/pubmed/28928276
http://dx.doi.org/10.1261/rna.063099.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689008/
https://www.ncbi.nlm.nih.gov/pubmed/28928276
http://dx.doi.org/10.1261/rna.063099.117

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