Cargando…

Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage

The insulin-induced gene 1 protein (Insig1) inhibits the cholesterol biosynthesis pathway by retaining transcription factor SREBP in the endoplasmic reticulum, and by causing the degradation of HMGCR, the rate-limiting enzyme in cholesterol biosynthesis. Liver-specific microRNA miR-122, on the other...

Descripción completa

Detalles Bibliográficos
Autores principales:	Norman, Kara L., Chen, Tzu-Chun, Zeiner, Gusti, Sarnow, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689008/ https://www.ncbi.nlm.nih.gov/pubmed/28928276 http://dx.doi.org/10.1261/rna.063099.117

Ejemplares similares

Regulation of INSIG2 by microRNA-96
por: Jo, Youngah, et al.
Publicado: (2017)

Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules
por: Cox, Erica Machlin, et al.
Publicado: (2013)

Characterization of mRNA polyadenylation in the apicomplexa
por: Stevens, Ashley T., et al.
Publicado: (2018)

EBV-regulated global changes in mRNA isoform usage
por: Homa, Nicholas, et al.
Publicado: (2012)

Molecular Insights into mRNA Polyadenylation and Deadenylation
por: Liu, Junjie, et al.
Publicado: (2022)

Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect
por: Chen, Tzu-Chun, et al.
Publicado: (2015)

Modified Polyadenylation-Based RT-qPCR Increases Selectivity of Amplification of 3′-MicroRNA Isoforms
por: Nejad, Charlotte, et al.
Publicado: (2018)

Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors
por: Gruber, Andreas R, et al.
Publicado: (2014)

The end of the message: multiple protein–RNA interactions define the mRNA polyadenylation site
por: Shi, Yongsheng, et al.
Publicado: (2015)

Alternative polyadenylation of mRNA and its role in cancer
por: Yuan, Fuwen, et al.
Publicado: (2019)

PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes
por: Lee, Ju Youn, et al.
Publicado: (2007)

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential
por: Malka, Yuval, et al.
Publicado: (2022)

Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes
por: Peros, Iván Gabriel, et al.
Publicado: (2020)

Signatures of mRNA Alternative Polyadenylation in Arabidopsis Leaf Development
por: Yu, Zhibo, et al.
Publicado: (2022)

Context-specific regulation and function of mRNA alternative polyadenylation
por: Mitschka, Sibylle, et al.
Publicado: (2022)

The nucleosome regulates the usage of polyadenylation sites in the human genome
por: Huang, Huan, et al.
Publicado: (2013)

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage
por: Dai, Weijun, et al.
Publicado: (2012)

Polyadenylation Linked to Transcription Termination Directs the Processing of snoRNA Precursors in Yeast
por: Grzechnik, Pawel, et al.
Publicado: (2008)

Characterization of the Distal Polyadenylation Site of the ß-Adducin (Add2) Pre-mRNA
por: Costessi, Luisa, et al.
Publicado: (2013)

microRNA-122 stimulates translation of hepatitis C virus RNA
por: Henke, Jura Inga, et al.
Publicado: (2008)

Liver-specific microRNA-122: Biogenesis and function
por: Jopling, Catherine
Publicado: (2012)

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development
por: Lin, Andrew C, et al.
Publicado: (2009)

Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs
por: Guvenek, Aysegul, et al.
Publicado: (2022)

Toxoplasma gondii Infection Specifically Increases the Levels of Key Host MicroRNAs
por: Zeiner, Gusti M., et al.
Publicado: (2010)

Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
por: Samuels, Tamsin J., et al.
Publicado: (2020)

PolyA_DB: a database for mammalian mRNA polyadenylation
por: Zhang, Haibo, et al.
Publicado: (2005)

New Links between mRNA Polyadenylation and Diverse Nuclear Pathways
por: Di Giammartino, Dafne Campigli, et al.
Publicado: (2014)

Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries
por: Grassi, Elena, et al.
Publicado: (2016)

Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation
por: Coll, Olga, et al.
Publicado: (2018)

Sequential Polyadenylation to Enable Alternative mRNA 3’ End Formation
por: Hao, Yajing, et al.
Publicado: (2023)

Sensitivity and specificity of microRNA‐122 for liver disease in dogs
por: Oosthuyzen, W., et al.
Publicado: (2018)

Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases
por: Liu, Ying, et al.
Publicado: (2020)

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening
por: Beaudoin, Jean-Denis, et al.
Publicado: (2013)

The main WAP isoform usually found in camel milk arises from the usage of an improbable intron cryptic splice site in the precursor to mRNA in which a GC-AG intron occurs
por: Ryskaliyeva, Alma, et al.
Publicado: (2019)

APADB: a database for alternative polyadenylation and microRNA regulation events
por: Müller, Sören, et al.
Publicado: (2014)

Post-Transcriptional Dysregulation of microRNA and Alternative Polyadenylation in Colorectal Cancer
por: Mao, Zhanrui, et al.
Publicado: (2020)

Polyadenylation of a functional mRNA controls gene expression in Escherichia coli
por: Joanny, Géraldine, et al.
Publicado: (2007)

A large-scale analysis of mRNA polyadenylation of human and mouse genes
por: Tian, Bin, et al.
Publicado: (2005)

HDA6-dependent histone deacetylation regulates mRNA polyadenylation in Arabidopsis
por: Lin, Juncheng, et al.
Publicado: (2020)

Alternative Polyadenylation Results in mRNA Transcript Instability in Gestational Diabetes Mellitus
por: He, Yujing, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3cs6r9150tunqil8dpq7gm3e07