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Topical application of ST266 reduces UV-induced skin damage

Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA da...

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Autores principales: Guan, Linna, Suggs, Amanda, Galan, Emily, Lam, Minh, Baron, Elma D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689067/
https://www.ncbi.nlm.nih.gov/pubmed/29184429
http://dx.doi.org/10.2147/CCID.S147112
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author Guan, Linna
Suggs, Amanda
Galan, Emily
Lam, Minh
Baron, Elma D
author_facet Guan, Linna
Suggs, Amanda
Galan, Emily
Lam, Minh
Baron, Elma D
author_sort Guan, Linna
collection PubMed
description Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Acutely, UVR causes skin inflammation and DNA damage, which manifest as sunburn (erythema). ST266 is the secretome of proprietary amnion-derived cells that have been shown to reduce inflammation and accelerate healing of various wounds by promoting migration of keratinocytes and fibroblasts in preclinical animal studies. We hypothesized that ST266 has anti-inflammatory effects that can be used to reduce ultraviolet (UV) erythema and markers of inflammation. In this study, we examined the in vivo effects of ST266 on post UV-irradiated skin by measuring erythema, level of cyclobutane pyrimidine dimer (CPD), and expression level of xeroderma pigmentosum, complementation group A (XPA). We demonstrated that ST266 has the potential to reduce the acute effects of UV-induced skin damage when applied immediately after the initial exposure. In addition, ST266 is shown to reduce erythema, increase XPA DNA repair protein, and decrease damaged DNA.
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spelling pubmed-56890672017-11-28 Topical application of ST266 reduces UV-induced skin damage Guan, Linna Suggs, Amanda Galan, Emily Lam, Minh Baron, Elma D Clin Cosmet Investig Dermatol Clinical Trial Report Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Acutely, UVR causes skin inflammation and DNA damage, which manifest as sunburn (erythema). ST266 is the secretome of proprietary amnion-derived cells that have been shown to reduce inflammation and accelerate healing of various wounds by promoting migration of keratinocytes and fibroblasts in preclinical animal studies. We hypothesized that ST266 has anti-inflammatory effects that can be used to reduce ultraviolet (UV) erythema and markers of inflammation. In this study, we examined the in vivo effects of ST266 on post UV-irradiated skin by measuring erythema, level of cyclobutane pyrimidine dimer (CPD), and expression level of xeroderma pigmentosum, complementation group A (XPA). We demonstrated that ST266 has the potential to reduce the acute effects of UV-induced skin damage when applied immediately after the initial exposure. In addition, ST266 is shown to reduce erythema, increase XPA DNA repair protein, and decrease damaged DNA. Dove Medical Press 2017-11-10 /pmc/articles/PMC5689067/ /pubmed/29184429 http://dx.doi.org/10.2147/CCID.S147112 Text en © 2017 Guan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Clinical Trial Report
Guan, Linna
Suggs, Amanda
Galan, Emily
Lam, Minh
Baron, Elma D
Topical application of ST266 reduces UV-induced skin damage
title Topical application of ST266 reduces UV-induced skin damage
title_full Topical application of ST266 reduces UV-induced skin damage
title_fullStr Topical application of ST266 reduces UV-induced skin damage
title_full_unstemmed Topical application of ST266 reduces UV-induced skin damage
title_short Topical application of ST266 reduces UV-induced skin damage
title_sort topical application of st266 reduces uv-induced skin damage
topic Clinical Trial Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689067/
https://www.ncbi.nlm.nih.gov/pubmed/29184429
http://dx.doi.org/10.2147/CCID.S147112
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