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Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus

BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure...

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Detalles Bibliográficos
Autores principales: Yokokawa, Tetsuro, Sato, Takamasa, Suzuki, Satoshi, Oikawa, Masayoshi, Yoshihisa, Akiomi, Kobayashi, Atsushi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Suzuki, Hitoshi, Saitoh, Shu-ichi, Ishida, Takafumi, Shimouchi, Akito, Takeishi, Yasuchika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689163/
https://www.ncbi.nlm.nih.gov/pubmed/29145814
http://dx.doi.org/10.1186/s12872-017-0713-0
Descripción
Sumario:BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. METHODS: This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. RESULTS: The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002). CONCLUSION: Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.