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Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus

BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure...

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Autores principales: Yokokawa, Tetsuro, Sato, Takamasa, Suzuki, Satoshi, Oikawa, Masayoshi, Yoshihisa, Akiomi, Kobayashi, Atsushi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Suzuki, Hitoshi, Saitoh, Shu-ichi, Ishida, Takafumi, Shimouchi, Akito, Takeishi, Yasuchika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689163/
https://www.ncbi.nlm.nih.gov/pubmed/29145814
http://dx.doi.org/10.1186/s12872-017-0713-0
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author Yokokawa, Tetsuro
Sato, Takamasa
Suzuki, Satoshi
Oikawa, Masayoshi
Yoshihisa, Akiomi
Kobayashi, Atsushi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-ichi
Ishida, Takafumi
Shimouchi, Akito
Takeishi, Yasuchika
author_facet Yokokawa, Tetsuro
Sato, Takamasa
Suzuki, Satoshi
Oikawa, Masayoshi
Yoshihisa, Akiomi
Kobayashi, Atsushi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-ichi
Ishida, Takafumi
Shimouchi, Akito
Takeishi, Yasuchika
author_sort Yokokawa, Tetsuro
collection PubMed
description BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. METHODS: This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. RESULTS: The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002). CONCLUSION: Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.
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spelling pubmed-56891632017-11-24 Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus Yokokawa, Tetsuro Sato, Takamasa Suzuki, Satoshi Oikawa, Masayoshi Yoshihisa, Akiomi Kobayashi, Atsushi Yamaki, Takayoshi Kunii, Hiroyuki Nakazato, Kazuhiko Suzuki, Hitoshi Saitoh, Shu-ichi Ishida, Takafumi Shimouchi, Akito Takeishi, Yasuchika BMC Cardiovasc Disord Research Article BACKGROUND: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. METHODS: This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. RESULTS: The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002). CONCLUSION: Stage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus. BioMed Central 2017-11-16 /pmc/articles/PMC5689163/ /pubmed/29145814 http://dx.doi.org/10.1186/s12872-017-0713-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yokokawa, Tetsuro
Sato, Takamasa
Suzuki, Satoshi
Oikawa, Masayoshi
Yoshihisa, Akiomi
Kobayashi, Atsushi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-ichi
Ishida, Takafumi
Shimouchi, Akito
Takeishi, Yasuchika
Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title_full Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title_fullStr Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title_full_unstemmed Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title_short Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus
title_sort elevated exhaled acetone concentration in stage c heart failure patients with diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689163/
https://www.ncbi.nlm.nih.gov/pubmed/29145814
http://dx.doi.org/10.1186/s12872-017-0713-0
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