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Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014

OBJECTIVE: To investigate changes in malaria prevalence in Papua New Guinea after the distribution of long-lasting Insecticide-treated nets, starting in 2004, and the introduction of artemisinin-based combination therapy in 2011. METHODS: Two malaria surveys were conducted in 2010–2011 and 2013–2014...

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Autores principales: Hetzel, Manuel W, Pulford, Justin, Ura, Yangta, Jamea-Maiasa, Sharon, Tandrapah, Anthony, Tarongka, Nandao, Lorry, Lina, Robinson, Leanne J, Lilley, Ken, Makita, Leo, Siba, Peter M, Mueller, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Health Organization 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689189/
https://www.ncbi.nlm.nih.gov/pubmed/29147042
http://dx.doi.org/10.2471/BLT.16.189902
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author Hetzel, Manuel W
Pulford, Justin
Ura, Yangta
Jamea-Maiasa, Sharon
Tandrapah, Anthony
Tarongka, Nandao
Lorry, Lina
Robinson, Leanne J
Lilley, Ken
Makita, Leo
Siba, Peter M
Mueller, Ivo
author_facet Hetzel, Manuel W
Pulford, Justin
Ura, Yangta
Jamea-Maiasa, Sharon
Tandrapah, Anthony
Tarongka, Nandao
Lorry, Lina
Robinson, Leanne J
Lilley, Ken
Makita, Leo
Siba, Peter M
Mueller, Ivo
author_sort Hetzel, Manuel W
collection PubMed
description OBJECTIVE: To investigate changes in malaria prevalence in Papua New Guinea after the distribution of long-lasting Insecticide-treated nets, starting in 2004, and the introduction of artemisinin-based combination therapy in 2011. METHODS: Two malaria surveys were conducted in 2010–2011 and 2013–2014. They included 77 and 92 randomly selected villages, respectively. In each village, all members of 30 randomly selected households gave blood samples and were assessed for malaria infection by light microscopy. In addition, data were obtained from a malaria survey performed in 2008–2009. RESULTS: The prevalence of malaria below 1600 m in altitude decreased from 11.1% (95% confidence interval, CI: 8.5–14.3) in 2008–2009 to 5.1% (95% CI 3.6–7.4) in 2010–2011 and 0.9% (95% CI 0.6–1.5) in 2013–2014. Prevalence decreased with altitude. Plasmodium falciparum was more common than P. vivax overall, but not everywhere, and initially the prevalence of P. vivax infection decreased more slowly than P. falciparum infection. Malaria infections were clustered in households. In contrast to findings in 2008–2009, no significant association between net use and prevalence was found in the later two surveys. The prevalence of both fever and splenomegaly also decreased but their association with malaria infection became stronger. CONCLUSION: Large-scale insecticide-treated net distribution was associated with an unprecedented decline in malaria prevalence throughout Papua New Guinea, including epidemic-prone highland areas. The decline was accompanied by broader health benefits, such as decreased morbidity. Better clinical management of nonmalarial fever and research into residual malaria transmission are required.
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spelling pubmed-56891892017-11-16 Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014 Hetzel, Manuel W Pulford, Justin Ura, Yangta Jamea-Maiasa, Sharon Tandrapah, Anthony Tarongka, Nandao Lorry, Lina Robinson, Leanne J Lilley, Ken Makita, Leo Siba, Peter M Mueller, Ivo Bull World Health Organ Research OBJECTIVE: To investigate changes in malaria prevalence in Papua New Guinea after the distribution of long-lasting Insecticide-treated nets, starting in 2004, and the introduction of artemisinin-based combination therapy in 2011. METHODS: Two malaria surveys were conducted in 2010–2011 and 2013–2014. They included 77 and 92 randomly selected villages, respectively. In each village, all members of 30 randomly selected households gave blood samples and were assessed for malaria infection by light microscopy. In addition, data were obtained from a malaria survey performed in 2008–2009. RESULTS: The prevalence of malaria below 1600 m in altitude decreased from 11.1% (95% confidence interval, CI: 8.5–14.3) in 2008–2009 to 5.1% (95% CI 3.6–7.4) in 2010–2011 and 0.9% (95% CI 0.6–1.5) in 2013–2014. Prevalence decreased with altitude. Plasmodium falciparum was more common than P. vivax overall, but not everywhere, and initially the prevalence of P. vivax infection decreased more slowly than P. falciparum infection. Malaria infections were clustered in households. In contrast to findings in 2008–2009, no significant association between net use and prevalence was found in the later two surveys. The prevalence of both fever and splenomegaly also decreased but their association with malaria infection became stronger. CONCLUSION: Large-scale insecticide-treated net distribution was associated with an unprecedented decline in malaria prevalence throughout Papua New Guinea, including epidemic-prone highland areas. The decline was accompanied by broader health benefits, such as decreased morbidity. Better clinical management of nonmalarial fever and research into residual malaria transmission are required. World Health Organization 2017-10-01 2017-09-05 /pmc/articles/PMC5689189/ /pubmed/29147042 http://dx.doi.org/10.2471/BLT.16.189902 Text en (c) 2017 The authors; licensee World Health Organization. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/licenses/by/3.0/igo/legalcode), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.
spellingShingle Research
Hetzel, Manuel W
Pulford, Justin
Ura, Yangta
Jamea-Maiasa, Sharon
Tandrapah, Anthony
Tarongka, Nandao
Lorry, Lina
Robinson, Leanne J
Lilley, Ken
Makita, Leo
Siba, Peter M
Mueller, Ivo
Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title_full Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title_fullStr Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title_full_unstemmed Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title_short Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008–2014
title_sort insecticide-treated nets and malaria prevalence, papua new guinea, 2008–2014
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689189/
https://www.ncbi.nlm.nih.gov/pubmed/29147042
http://dx.doi.org/10.2471/BLT.16.189902
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