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Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor
This report describes the case of a 65‐year‐old male who complained of muscular weakness of the legs with easy fatigability. Blood and imaging examinations showed positive anti‐acetylcholine receptor antibody and an anterior mediastinal tumor (probably a thymic cyst), suggesting the diagnosis of mya...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689432/ https://www.ncbi.nlm.nih.gov/pubmed/29264043 http://dx.doi.org/10.1002/jgf2.66 |
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author | Matsumoto, Hideyuki Ohtomo, Gaku Akahori, Tsugumi Hashida, Hideji |
author_facet | Matsumoto, Hideyuki Ohtomo, Gaku Akahori, Tsugumi Hashida, Hideji |
author_sort | Matsumoto, Hideyuki |
collection | PubMed |
description | This report describes the case of a 65‐year‐old male who complained of muscular weakness of the legs with easy fatigability. Blood and imaging examinations showed positive anti‐acetylcholine receptor antibody and an anterior mediastinal tumor (probably a thymic cyst), suggesting the diagnosis of myasthenia gravis (MG). However, neurological and electrophysiological examinations suggested the diagnosis of Lambert‐Eaton myasthenic syndrome (LEMS). We searched repeatedly for malignant tumors. Small cell lung cancer (SCLC) was found. Chemotherapy reduced the SCLC and improved the patient's clinical symptoms. On the basis of an accurate diagnosis of LEMS, we were able to detect SCLC and administer chemotherapy at an early stage. Anti‐P/Q‐type voltage‐gated calcium channel antibody was negative. In our case, MG and LEMS overlap syndrome in addition to MG should be differentiated. For the differentiation, the strict electrophysiological criteria of LEMS were useful. |
format | Online Article Text |
id | pubmed-5689432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56894322017-12-20 Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor Matsumoto, Hideyuki Ohtomo, Gaku Akahori, Tsugumi Hashida, Hideji J Gen Fam Med Case Reports This report describes the case of a 65‐year‐old male who complained of muscular weakness of the legs with easy fatigability. Blood and imaging examinations showed positive anti‐acetylcholine receptor antibody and an anterior mediastinal tumor (probably a thymic cyst), suggesting the diagnosis of myasthenia gravis (MG). However, neurological and electrophysiological examinations suggested the diagnosis of Lambert‐Eaton myasthenic syndrome (LEMS). We searched repeatedly for malignant tumors. Small cell lung cancer (SCLC) was found. Chemotherapy reduced the SCLC and improved the patient's clinical symptoms. On the basis of an accurate diagnosis of LEMS, we were able to detect SCLC and administer chemotherapy at an early stage. Anti‐P/Q‐type voltage‐gated calcium channel antibody was negative. In our case, MG and LEMS overlap syndrome in addition to MG should be differentiated. For the differentiation, the strict electrophysiological criteria of LEMS were useful. John Wiley and Sons Inc. 2017-04-13 /pmc/articles/PMC5689432/ /pubmed/29264043 http://dx.doi.org/10.1002/jgf2.66 Text en © 2017 The Authors. Journal of General and Family Medicine published by John Wiley & Sons Australia, Ltd on behalf of Japan Primary Care Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Matsumoto, Hideyuki Ohtomo, Gaku Akahori, Tsugumi Hashida, Hideji Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title | Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title_full | Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title_fullStr | Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title_full_unstemmed | Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title_short | Lambert‐Eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
title_sort | lambert‐eaton myasthenic syndrome with anti‐acetylcholine receptor antibody and anterior mediastinal tumor |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689432/ https://www.ncbi.nlm.nih.gov/pubmed/29264043 http://dx.doi.org/10.1002/jgf2.66 |
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