Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection

Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon...

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Detalles Bibliográficos
Autores principales: Wiraja, Christian, Mathiyazhakan, Malathi, Movahedi, Fatemeh, Upputuri, Paul Kumar, Cheng, Yingying, Pramanik, Manojit, Yang, Liang, Becker, David Laurence, Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689532/
https://www.ncbi.nlm.nih.gov/pubmed/29313020
http://dx.doi.org/10.1002/btm2.10020
Descripción
Sumario:Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.

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