Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection

Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon...

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Autores principales: Wiraja, Christian, Mathiyazhakan, Malathi, Movahedi, Fatemeh, Upputuri, Paul Kumar, Cheng, Yingying, Pramanik, Manojit, Yang, Liang, Becker, David Laurence, Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689532/
https://www.ncbi.nlm.nih.gov/pubmed/29313020
http://dx.doi.org/10.1002/btm2.10020
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author Wiraja, Christian
Mathiyazhakan, Malathi
Movahedi, Fatemeh
Upputuri, Paul Kumar
Cheng, Yingying
Pramanik, Manojit
Yang, Liang
Becker, David Laurence
Xu, Chenjie
author_facet Wiraja, Christian
Mathiyazhakan, Malathi
Movahedi, Fatemeh
Upputuri, Paul Kumar
Cheng, Yingying
Pramanik, Manojit
Yang, Liang
Becker, David Laurence
Xu, Chenjie
author_sort Wiraja, Christian
collection PubMed
description Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.
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spelling pubmed-56895322018-01-08 Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection Wiraja, Christian Mathiyazhakan, Malathi Movahedi, Fatemeh Upputuri, Paul Kumar Cheng, Yingying Pramanik, Manojit Yang, Liang Becker, David Laurence Xu, Chenjie Bioeng Transl Med Research Reports Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment. John Wiley and Sons Inc. 2016-07-29 /pmc/articles/PMC5689532/ /pubmed/29313020 http://dx.doi.org/10.1002/btm2.10020 Text en © 2016 The Authors. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Reports
Wiraja, Christian
Mathiyazhakan, Malathi
Movahedi, Fatemeh
Upputuri, Paul Kumar
Cheng, Yingying
Pramanik, Manojit
Yang, Liang
Becker, David Laurence
Xu, Chenjie
Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title_full Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title_fullStr Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title_full_unstemmed Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title_short Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection
title_sort near‐infrared light‐sensitive liposomes for enhanced plasmid dna transfection
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689532/
https://www.ncbi.nlm.nih.gov/pubmed/29313020
http://dx.doi.org/10.1002/btm2.10020
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