Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways

Pediatric low-grade gliomas (PLGGs) are frequently associated with activating BRAF gene fusions, such as KIAA1549-BRAF, that aberrantly drive the mitogen activated protein kinase (MAPK) pathway. Although RAF inhibitors (RAFi) have been proven effective in BRAF-V600E mutant tumors, we have previously...

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Detalles Bibliográficos
Autores principales: Jain, Payal, Silva, Amanda, Han, Harry J., Lang, Shih-Shan, Zhu, Yuankun, Boucher, Katie, Smith, Tiffany E., Vakil, Aesha, Diviney, Patrick, Choudhari, Namrata, Raman, Pichai, Busch, Christine M., Delaney, Tim, Yang, Xiaodong, Olow, Aleksandra K., Mueller, Sabine, Haas-Kogan, Daphne, Fox, Elizabeth, Storm, Phillip B., Resnick, Adam C., Waanders, Angela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689567/
https://www.ncbi.nlm.nih.gov/pubmed/29156677
http://dx.doi.org/10.18632/oncotarget.20949

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