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Oligomer procyanidins (F2) repress HIF-1α expression in human U87 glioma cells by inhibiting the EGFR/ AKT/mTOR and MAPK/ERK1/2 signaling pathways in vitro and in vivo

Hypoxia-inducible factor-1 (HIF-1) is over-expressed in gliomas and has become one of the most compelling tumor targets. In this study, we found that oligomer procyanidins (F2) can suppress the expressions of HIF-1α and its target genes in U87 cells, and also down-regulate the EGFR/PI3K/AKT/mTOR and...

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Detalles Bibliográficos
Autores principales:	Zheng, Hong-Li, Wang, Li-Hui, Sun, Bao-Shan, Li, Yi, Yang, Jing-Yu, Wu, Chun-Fu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689607/ https://www.ncbi.nlm.nih.gov/pubmed/29156717 http://dx.doi.org/10.18632/oncotarget.19654

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