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Dietary inflammatory index and the risk of gastric cancer in a Korean population

We aimed to investigate the association with the Dietary Inflammatory Index (DII™) on the risk of gastric cancer and whether histological type modifies this association. From March 2011 to December 2014, 388 cases and 776 controls were enrolled at the National Cancer Center. Utilizing a food frequen...

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Autores principales: Lee, Sunghee, Lee, Jeonghee, Choi, Il Ju, Kim, Young-Woo, Ryu, Keun Won, Kim, Young-Il, Oh, Jin-Kyoung, Tran, Binh Thang, Kim, Jeongseon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689622/
https://www.ncbi.nlm.nih.gov/pubmed/29156732
http://dx.doi.org/10.18632/oncotarget.20008
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author Lee, Sunghee
Lee, Jeonghee
Choi, Il Ju
Kim, Young-Woo
Ryu, Keun Won
Kim, Young-Il
Oh, Jin-Kyoung
Tran, Binh Thang
Kim, Jeongseon
author_facet Lee, Sunghee
Lee, Jeonghee
Choi, Il Ju
Kim, Young-Woo
Ryu, Keun Won
Kim, Young-Il
Oh, Jin-Kyoung
Tran, Binh Thang
Kim, Jeongseon
author_sort Lee, Sunghee
collection PubMed
description We aimed to investigate the association with the Dietary Inflammatory Index (DII™) on the risk of gastric cancer and whether histological type modifies this association. From March 2011 to December 2014, 388 cases and 776 controls were enrolled at the National Cancer Center. Utilizing a food frequency questionnaire, thirty-five food components were used to score the DII. The tertile distribution of DII for controls was as follows: T1: <0.96, T2: 0.96-2.97, and T3: ≥2.97. To investigate the association between DII and the gastric cancer risk, multivariable logistic models were constructed. In subgroup analyses, histological types including intestinal and diffuse types were examined. As the DII increased, gastric cancer risk increased (p-value for trend =0.007). Participants in the highest DII tertile had a greater gastric cancer risk compared to those in the lowest tertile [Odds Ratio (OR) =1.63, 95% Confidence Interval (CI) 1.15-2.29]. Stratification by sex revealed that men who were in the highest DII tertile showed a greater risk of intestinal type (OR=2.03, 95% CI 1.09-3.77). Participants positive for H. pylori infection had higher risk of intestinal type (OR=2.16, 95% CI 1.21-3.87). In this case-control study, we found a significantly positive association with a pro-inflammatory diet on gastric cancer risk, after adjusting for covariates. Future studies are suggested to prospectively examine the effect of a pro-inflammatory diet on gastric cancer risk.
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spelling pubmed-56896222017-11-17 Dietary inflammatory index and the risk of gastric cancer in a Korean population Lee, Sunghee Lee, Jeonghee Choi, Il Ju Kim, Young-Woo Ryu, Keun Won Kim, Young-Il Oh, Jin-Kyoung Tran, Binh Thang Kim, Jeongseon Oncotarget Research Paper We aimed to investigate the association with the Dietary Inflammatory Index (DII™) on the risk of gastric cancer and whether histological type modifies this association. From March 2011 to December 2014, 388 cases and 776 controls were enrolled at the National Cancer Center. Utilizing a food frequency questionnaire, thirty-five food components were used to score the DII. The tertile distribution of DII for controls was as follows: T1: <0.96, T2: 0.96-2.97, and T3: ≥2.97. To investigate the association between DII and the gastric cancer risk, multivariable logistic models were constructed. In subgroup analyses, histological types including intestinal and diffuse types were examined. As the DII increased, gastric cancer risk increased (p-value for trend =0.007). Participants in the highest DII tertile had a greater gastric cancer risk compared to those in the lowest tertile [Odds Ratio (OR) =1.63, 95% Confidence Interval (CI) 1.15-2.29]. Stratification by sex revealed that men who were in the highest DII tertile showed a greater risk of intestinal type (OR=2.03, 95% CI 1.09-3.77). Participants positive for H. pylori infection had higher risk of intestinal type (OR=2.16, 95% CI 1.21-3.87). In this case-control study, we found a significantly positive association with a pro-inflammatory diet on gastric cancer risk, after adjusting for covariates. Future studies are suggested to prospectively examine the effect of a pro-inflammatory diet on gastric cancer risk. Impact Journals LLC 2017-08-07 /pmc/articles/PMC5689622/ /pubmed/29156732 http://dx.doi.org/10.18632/oncotarget.20008 Text en Copyright: © 2017 Lee et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lee, Sunghee
Lee, Jeonghee
Choi, Il Ju
Kim, Young-Woo
Ryu, Keun Won
Kim, Young-Il
Oh, Jin-Kyoung
Tran, Binh Thang
Kim, Jeongseon
Dietary inflammatory index and the risk of gastric cancer in a Korean population
title Dietary inflammatory index and the risk of gastric cancer in a Korean population
title_full Dietary inflammatory index and the risk of gastric cancer in a Korean population
title_fullStr Dietary inflammatory index and the risk of gastric cancer in a Korean population
title_full_unstemmed Dietary inflammatory index and the risk of gastric cancer in a Korean population
title_short Dietary inflammatory index and the risk of gastric cancer in a Korean population
title_sort dietary inflammatory index and the risk of gastric cancer in a korean population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689622/
https://www.ncbi.nlm.nih.gov/pubmed/29156732
http://dx.doi.org/10.18632/oncotarget.20008
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