Cargando…

Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model

An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant methioninase (rMETase). The present study used a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawaguchi, Kei, Igarashi, Kentaro, Li, Shukuan, Han, Qinghong, Tan, Yuying, Kiyuna, Tasuku, Miyake, Kentaro, Murakami, Takashi, Chmielowski, Bartosz, Nelson, Scott D., Russell, Tara A., Dry, Sarah M., Li, Yunfeng, Unno, Michiaki, Eilber, Fritz C., Hoffman, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689627/ https://www.ncbi.nlm.nih.gov/pubmed/29156737 http://dx.doi.org/10.18632/oncotarget.20231

Ejemplares similares

Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models
por: Kawaguchi, Kei, et al.
Publicado: (2017)

Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model
por: Murakami, Takashi, et al.
Publicado: (2017)

Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
por: Kawaguchi, Kei, et al.
Publicado: (2019)

Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model
por: Igarashi, Kentaro, et al.
Publicado: (2018)

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model
por: Kawaguchi, Kei, et al.
Publicado: (2016)

Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model
por: Kawaguchi, Kei, et al.
Publicado: (2016)

Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models
por: Kawaguchi, Kei, et al.
Publicado: (2018)

Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model
por: Igarashi, Kentaro, et al.
Publicado: (2017)

A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology
por: Igarashi, Kentaro, et al.
Publicado: (2017)

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model
por: Igarashi, Kentaro, et al.
Publicado: (2017)

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model
por: Kiyuna, Tasuku, et al.
Publicado: (2018)

A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX)
por: Igarashi, Kentaro, et al.
Publicado: (2017)

The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy
por: Miyake, Kentaro, et al.
Publicado: (2017)

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)
por: Kawaguchi, Kei, et al.
Publicado: (2017)

High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model
por: Kiyuna, Tasuku, et al.
Publicado: (2016)

Efficacy of Tumor-Targeting Salmonella typhimurium A1-R against Malignancies in Patient-Derived Orthotopic Xenograft (PDOX) Murine Models
por: Murakami, Takashi, et al.
Publicado: (2019)

A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations
por: Zhang, Zhiying, et al.
Publicado: (2020)

Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model
por: Murakami, Takashi, et al.
Publicado: (2016)

Selective methioninase-induced trap of cancer cells in S/G(2) phase visualized by FUCCI imaging confers chemosensitivity
por: Yano, Shuya, et al.
Publicado: (2014)

Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model
por: Igarashi, Kentaro, et al.
Publicado: (2019)

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma †
por: Hoffman, Robert M.
Publicado: (2017)

High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models
por: Kawaguchi, Kei, et al.
Publicado: (2016)

Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy, and tumor-targeting S. typhimurium A1-R is superior to first-line chemotherapy
por: Miyake, Kentaro, et al.
Publicado: (2018)

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model
por: Yamamoto, Mako, et al.
Publicado: (2016)

Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma
por: Zhang, Huiyuan, et al.
Publicado: (2020)

Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model
por: Lwin, Thinzar M., et al.
Publicado: (2018)

Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application
por: Higuchi, Takashi, et al.
Publicado: (2022)

Toxicology and efficacy of tumor-targeting Salmonella typhimurium A1-R compared to VNP 20009 in a syngeneic mouse tumor model in immunocompetent mice
por: Zhang, Yong, et al.
Publicado: (2017)

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model
por: Murakami, Takashi, et al.
Publicado: (2016)

An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model
por: Oshiro, Hiromichi, et al.
Publicado: (2021)

Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model
por: Zhu, Guangwei, et al.
Publicado: (2020)

Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations
por: Miyake, Kentaro, et al.
Publicado: (2018)

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug
por: Murakami, Takashi, et al.
Publicado: (2016)

Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern
por: Hiroshima, Yukihiko, et al.
Publicado: (2015)

High-fat diet promotes tumor growth in the patient-derived orthotopic xenograft (PDOX) mouse model of ER positive endometrial cancer
por: Shen, Ke, et al.
Publicado: (2023)

Purification, Characterization of L-Methioninase from Candida tropicalis, and Its Application as an Anticancer
por: Selim, Mohsen Helmy, et al.
Publicado: (2015)

Isolation and characterization of Trichoderma harzianum L-methioninase with promising a powerful anticancer
por: Ashkan, Mada F., et al.
Publicado: (2023)

Bacterium Hafnia alvei secretes l-methioninase enzyme: Optimization of the enzyme secretion conditions
por: Alshehri, Wafa A.
Publicado: (2020)

Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation
por: Aoki, Yusuke, et al.
Publicado: (2021)

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery
por: Yano, Shuya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_m2jpggv6b53h8c53667764ouk3