High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity

Bone metastases often occur in prostate cancers, lung cancers and breast cancers. Bone alkaline phosphatase (BALP) is one of the most commonly used serological markers for clinical evaluation of bone metabolism. Here, we reported that high concentrations of uric acid (UA) caused decrease of BALP lev...

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Autores principales: Wu, Zhi-Qi, Chen, Xiao-Ting, Xu, Yan-Yan, Tian, Ming-Jie, Chen, Hai-Yan, Zhou, Guo-Ping, Xu, Hua-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689639/
https://www.ncbi.nlm.nih.gov/pubmed/29156749
http://dx.doi.org/10.18632/oncotarget.21110
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author Wu, Zhi-Qi
Chen, Xiao-Ting
Xu, Yan-Yan
Tian, Ming-Jie
Chen, Hai-Yan
Zhou, Guo-Ping
Xu, Hua-Guo
author_facet Wu, Zhi-Qi
Chen, Xiao-Ting
Xu, Yan-Yan
Tian, Ming-Jie
Chen, Hai-Yan
Zhou, Guo-Ping
Xu, Hua-Guo
author_sort Wu, Zhi-Qi
collection PubMed
description Bone metastases often occur in prostate cancers, lung cancers and breast cancers. Bone alkaline phosphatase (BALP) is one of the most commonly used serological markers for clinical evaluation of bone metabolism. Here, we reported that high concentrations of uric acid (UA) caused decrease of BALP levels and revealed that the effect of high concentrations of UA on the BALP expression was through inhibition of its promoter activity. Our results suggested physicians to think about serum UA status of patients with advanced cancer to avoid misdiagnosis when BALP was used to diagnose or assess the extent of bone metastases.
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spelling pubmed-56896392017-11-17 High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity Wu, Zhi-Qi Chen, Xiao-Ting Xu, Yan-Yan Tian, Ming-Jie Chen, Hai-Yan Zhou, Guo-Ping Xu, Hua-Guo Oncotarget Research Paper Bone metastases often occur in prostate cancers, lung cancers and breast cancers. Bone alkaline phosphatase (BALP) is one of the most commonly used serological markers for clinical evaluation of bone metabolism. Here, we reported that high concentrations of uric acid (UA) caused decrease of BALP levels and revealed that the effect of high concentrations of UA on the BALP expression was through inhibition of its promoter activity. Our results suggested physicians to think about serum UA status of patients with advanced cancer to avoid misdiagnosis when BALP was used to diagnose or assess the extent of bone metastases. Impact Journals LLC 2017-09-20 /pmc/articles/PMC5689639/ /pubmed/29156749 http://dx.doi.org/10.18632/oncotarget.21110 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Zhi-Qi
Chen, Xiao-Ting
Xu, Yan-Yan
Tian, Ming-Jie
Chen, Hai-Yan
Zhou, Guo-Ping
Xu, Hua-Guo
High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title_full High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title_fullStr High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title_full_unstemmed High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title_short High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity
title_sort high uric acid (ua) downregulates bone alkaline phosphatase (balp) expression through inhibition of its promoter activity
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689639/
https://www.ncbi.nlm.nih.gov/pubmed/29156749
http://dx.doi.org/10.18632/oncotarget.21110
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