The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation

Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of the replication fork. The rs5745906 SNP of the NEIL1 gene is a rare human germline variant that encodes the NEIL1 G83D protein, which is devoid...

Descripción completa

Detalles Bibliográficos
Autores principales: Galick, Heather A., Marsden, Carolyn G., Kathe, Scott, Dragon, Julie A., Volk, Lindsay, Nemec, Antonia A., Wallace, Susan S., Prakash, Aishwarya, Doublié, Sylvie, Sweasy, Joann B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689654/
https://www.ncbi.nlm.nih.gov/pubmed/29156764
http://dx.doi.org/10.18632/oncotarget.20716

Ejemplares similares

Ejemplares similares