Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability

Surgical removal of colorectal cancer (CRC) liver metastases generates areas of tissue hypoxia. Hypoxia imposes a stem-like phenotype on residual tumor cells and promotes tumor recurrence. Moreover, in primary CRC, gene expression signatures reflecting hypoxia and a stem-like phenotype are highly ex...

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Detalles Bibliográficos
Autores principales: Jongen, Jennifer M. J., van der Waals, Lizet M., Trumpi, Kari, Laoukili, Jamila, Peters, Niek A., Schenning-van Schelven, Susanne J., Govaert, Klaas M., Borel Rinkes, Inne H. M., Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689686/
https://www.ncbi.nlm.nih.gov/pubmed/29156796
http://dx.doi.org/10.18632/oncotarget.21145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689686/
https://www.ncbi.nlm.nih.gov/pubmed/29156796
http://dx.doi.org/10.18632/oncotarget.21145

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