HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression

Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the mol...

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Autores principales: Ma, Jian, Fan, Yanxin, Feng, Tingting, Chen, Fangjun, Xu, Zhipeng, Li, Suqing, Lin, Qingfeng, He, Xiaoting, Shi, Weihong, Liu, Yang, Cao, Xiufeng, Zhu, Bin, Liu, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689694/
https://www.ncbi.nlm.nih.gov/pubmed/29156804
http://dx.doi.org/10.18632/oncotarget.21195
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author Ma, Jian
Fan, Yanxin
Feng, Tingting
Chen, Fangjun
Xu, Zhipeng
Li, Suqing
Lin, Qingfeng
He, Xiaoting
Shi, Weihong
Liu, Yang
Cao, Xiufeng
Zhu, Bin
Liu, Zhihua
author_facet Ma, Jian
Fan, Yanxin
Feng, Tingting
Chen, Fangjun
Xu, Zhipeng
Li, Suqing
Lin, Qingfeng
He, Xiaoting
Shi, Weihong
Liu, Yang
Cao, Xiufeng
Zhu, Bin
Liu, Zhihua
author_sort Ma, Jian
collection PubMed
description Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The “competitive endogenous RNA” (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy.
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spelling pubmed-56896942017-11-17 HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression Ma, Jian Fan, Yanxin Feng, Tingting Chen, Fangjun Xu, Zhipeng Li, Suqing Lin, Qingfeng He, Xiaoting Shi, Weihong Liu, Yang Cao, Xiufeng Zhu, Bin Liu, Zhihua Oncotarget Research Paper Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The “competitive endogenous RNA” (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy. Impact Journals LLC 2017-09-23 /pmc/articles/PMC5689694/ /pubmed/29156804 http://dx.doi.org/10.18632/oncotarget.21195 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ma, Jian
Fan, Yanxin
Feng, Tingting
Chen, Fangjun
Xu, Zhipeng
Li, Suqing
Lin, Qingfeng
He, Xiaoting
Shi, Weihong
Liu, Yang
Cao, Xiufeng
Zhu, Bin
Liu, Zhihua
HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title_full HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title_fullStr HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title_full_unstemmed HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title_short HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
title_sort hotair regulates hk2 expression by binding endogenous mir-125 and mir-143 in oesophageal squamous cell carcinoma progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689694/
https://www.ncbi.nlm.nih.gov/pubmed/29156804
http://dx.doi.org/10.18632/oncotarget.21195
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