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The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis
Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Registe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689729/ https://www.ncbi.nlm.nih.gov/pubmed/29156839 http://dx.doi.org/10.18632/oncotarget.20045 |
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author | Zhang, Chengshuo Chen, Baomin Jiao, Ao Li, Feng Wang, Bowen Sun, Ning Zhang, Jialin |
author_facet | Zhang, Chengshuo Chen, Baomin Jiao, Ao Li, Feng Wang, Bowen Sun, Ning Zhang, Jialin |
author_sort | Zhang, Chengshuo |
collection | PubMed |
description | Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016. Data extraction and quality assessment of RCTs were performed in accordance with PRISMA guidelines. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis. A random-effects model was used to conduct a meta-analysis with RevMan 5.3.5 software. Eight RCTs including 805 patients (402 with and 403 without immunonutrition) were identified. Immunonutrition, mainly ω-3 fatty acids, significantly reduced the incidence of postoperative total complications (risk ratio [RR] = 0.59; 95% confidence interval [CI], 0.46–0.75; p < 0.0001) and infectious complications (RR = 0.46; 95% CI, 0.32–0.68; p < 0.0001), and shortened the length of hospital stay (standardized mean difference, −0.49; 95% CI, −0.81 to −0.16; p = 0.0004). There was no significant between-group difference in postoperative mortality (RR = 0.46; 95% CI, 0.16–1.31; p = 0.15). Immunonutrition, mainly ω-3 fatty acids, is potentially beneficial in reducing overall and infectious postoperative complications and in shortening the hospital stay for patients undergoing hepatectomy. |
format | Online Article Text |
id | pubmed-5689729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56897292017-11-17 The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis Zhang, Chengshuo Chen, Baomin Jiao, Ao Li, Feng Wang, Bowen Sun, Ning Zhang, Jialin Oncotarget Meta-Analysis Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016. Data extraction and quality assessment of RCTs were performed in accordance with PRISMA guidelines. The quality of evidence for each postoperative outcome was assessed using the GRADEpro analysis. A random-effects model was used to conduct a meta-analysis with RevMan 5.3.5 software. Eight RCTs including 805 patients (402 with and 403 without immunonutrition) were identified. Immunonutrition, mainly ω-3 fatty acids, significantly reduced the incidence of postoperative total complications (risk ratio [RR] = 0.59; 95% confidence interval [CI], 0.46–0.75; p < 0.0001) and infectious complications (RR = 0.46; 95% CI, 0.32–0.68; p < 0.0001), and shortened the length of hospital stay (standardized mean difference, −0.49; 95% CI, −0.81 to −0.16; p = 0.0004). There was no significant between-group difference in postoperative mortality (RR = 0.46; 95% CI, 0.16–1.31; p = 0.15). Immunonutrition, mainly ω-3 fatty acids, is potentially beneficial in reducing overall and infectious postoperative complications and in shortening the hospital stay for patients undergoing hepatectomy. Impact Journals LLC 2017-08-08 /pmc/articles/PMC5689729/ /pubmed/29156839 http://dx.doi.org/10.18632/oncotarget.20045 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Zhang, Chengshuo Chen, Baomin Jiao, Ao Li, Feng Wang, Bowen Sun, Ning Zhang, Jialin The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title | The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title_full | The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title_fullStr | The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title_full_unstemmed | The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title_short | The benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
title_sort | benefit of immunonutrition in patients undergoing hepatectomy: a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689729/ https://www.ncbi.nlm.nih.gov/pubmed/29156839 http://dx.doi.org/10.18632/oncotarget.20045 |
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