Concise Review: Developing Best‐Practice Models for the Therapeutic Use of Extracellular Vesicles

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell‐related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Ve...

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Detalles Bibliográficos
Autores principales: Reiner, Agnes T., Witwer, Kenneth W., van Balkom, Bas W.M., de Beer, Joel, Brodie, Chaya, Corteling, Randolph L., Gabrielsson, Susanne, Gimona, Mario, Ibrahim, Ahmed G., de Kleijn, Dominique, Lai, Charles P., Lötvall, Jan, del Portillo, Hernando A., Reischl, Ilona G., Riazifar, Milad, Salomon, Carlos, Tahara, Hidetoshi, Toh, Wei Seong, Wauben, Marca H.M., Yang, Vicky K., Yang, Yijun, Yeo, Ronne Wee Yeh, Yin, Hang, Giebel, Bernd, Rohde, Eva, Lim, Sai Kiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Translational Research Articles and Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689784/
https://www.ncbi.nlm.nih.gov/pubmed/28714557
http://dx.doi.org/10.1002/sctm.17-0055
Descripción
Sumario:Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell‐related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV‐based therapeutics at the preclinical and clinical levels. This review outlines topic‐specific action items that, if addressed, will enhance the development of best‐practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730–1739

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