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Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film

PURPOSE: Magnetic resonance image (MRI) guided radiotherapy enables gating directly on the target position. We present an evaluation of an MRI‐guided radiotherapy system's gating performance using an MRI‐compatible respiratory motion phantom and radiochromic film. Our evaluation is geared towar...

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Autores principales: Lamb, James M., Ginn, John S., O'Connell, Dylan P., Agazaryan, Nzhde, Cao, Minsong, Thomas, David H., Yang, Yingli, Lazea, Mircea, Lee, Percy, Low, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689863/
https://www.ncbi.nlm.nih.gov/pubmed/28436094
http://dx.doi.org/10.1002/acm2.12088
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author Lamb, James M.
Ginn, John S.
O'Connell, Dylan P.
Agazaryan, Nzhde
Cao, Minsong
Thomas, David H.
Yang, Yingli
Lazea, Mircea
Lee, Percy
Low, Daniel A.
author_facet Lamb, James M.
Ginn, John S.
O'Connell, Dylan P.
Agazaryan, Nzhde
Cao, Minsong
Thomas, David H.
Yang, Yingli
Lazea, Mircea
Lee, Percy
Low, Daniel A.
author_sort Lamb, James M.
collection PubMed
description PURPOSE: Magnetic resonance image (MRI) guided radiotherapy enables gating directly on the target position. We present an evaluation of an MRI‐guided radiotherapy system's gating performance using an MRI‐compatible respiratory motion phantom and radiochromic film. Our evaluation is geared toward validation of our institution's clinical gating protocol which involves planning to a target volume formed by expanding 5 mm about the gross tumor volume (GTV) and gating based on a 3 mm window about the GTV. METHODS: The motion phantom consisted of a target rod containing high‐contrast target inserts which moved in the superior‐inferior direction inside a body structure containing background contrast material. The target rod was equipped with a radiochromic film insert. Treatment plans were generated for a 3 cm diameter spherical planning target volume, and delivered to the phantom at rest and in motion with and without gating. Both sinusoidal trajectories and tumor trajectories measured during MRI‐guided treatments were used. Similarity of the gated dose distribution to the planned, motion‐frozen, distribution was quantified using the gamma technique. RESULTS: Without gating, gamma pass rates using 4%/3 mm criteria were 22–59% depending on motion trajectory. Using our clinical standard of repeated breath holds and a gating window of 3 mm with 10% target allowed outside the gating boundary, the gamma pass rate was 97.8% with 3%/3 mm gamma criteria. Using a 3 mm window and 10% allowed excursion, all of the patient tumor motion trajectories at actual speed resulting in at least 95% gamma pass rate at 4%/3 mm. CONCLUSIONS: Our results suggest that the device can be used to compensate respiratory motion using a 3 mm gating margin and 10% allowed excursion results in conjunction with repeated breath holds. Full clinical validation requires a comprehensive evaluation of tracking performance in actual patient images, outside the scope of this study.
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spelling pubmed-56898632018-04-02 Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film Lamb, James M. Ginn, John S. O'Connell, Dylan P. Agazaryan, Nzhde Cao, Minsong Thomas, David H. Yang, Yingli Lazea, Mircea Lee, Percy Low, Daniel A. J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: Magnetic resonance image (MRI) guided radiotherapy enables gating directly on the target position. We present an evaluation of an MRI‐guided radiotherapy system's gating performance using an MRI‐compatible respiratory motion phantom and radiochromic film. Our evaluation is geared toward validation of our institution's clinical gating protocol which involves planning to a target volume formed by expanding 5 mm about the gross tumor volume (GTV) and gating based on a 3 mm window about the GTV. METHODS: The motion phantom consisted of a target rod containing high‐contrast target inserts which moved in the superior‐inferior direction inside a body structure containing background contrast material. The target rod was equipped with a radiochromic film insert. Treatment plans were generated for a 3 cm diameter spherical planning target volume, and delivered to the phantom at rest and in motion with and without gating. Both sinusoidal trajectories and tumor trajectories measured during MRI‐guided treatments were used. Similarity of the gated dose distribution to the planned, motion‐frozen, distribution was quantified using the gamma technique. RESULTS: Without gating, gamma pass rates using 4%/3 mm criteria were 22–59% depending on motion trajectory. Using our clinical standard of repeated breath holds and a gating window of 3 mm with 10% target allowed outside the gating boundary, the gamma pass rate was 97.8% with 3%/3 mm gamma criteria. Using a 3 mm window and 10% allowed excursion, all of the patient tumor motion trajectories at actual speed resulting in at least 95% gamma pass rate at 4%/3 mm. CONCLUSIONS: Our results suggest that the device can be used to compensate respiratory motion using a 3 mm gating margin and 10% allowed excursion results in conjunction with repeated breath holds. Full clinical validation requires a comprehensive evaluation of tracking performance in actual patient images, outside the scope of this study. John Wiley and Sons Inc. 2017-04-24 /pmc/articles/PMC5689863/ /pubmed/28436094 http://dx.doi.org/10.1002/acm2.12088 Text en © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Lamb, James M.
Ginn, John S.
O'Connell, Dylan P.
Agazaryan, Nzhde
Cao, Minsong
Thomas, David H.
Yang, Yingli
Lazea, Mircea
Lee, Percy
Low, Daniel A.
Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title_full Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title_fullStr Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title_full_unstemmed Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title_short Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
title_sort dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689863/
https://www.ncbi.nlm.nih.gov/pubmed/28436094
http://dx.doi.org/10.1002/acm2.12088
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