Cargando…

Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy

Deep inspiration breath‐hold (DIBH) radiotherapy for left‐sided breast cancer can reduce cardiac exposure and internal motion. We modified our in‐house treatment planning system (TPS) to retrospectively analyze breath‐hold motion log files to calculate the dosimetric effect of the motion during brea...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Xiaoli, Cullip, Tim, Dooley, John, Zagar, Timothy, Jones, Ellen, Chang, Sha, Zhu, Xiaofeng, Lian, Jun, Marks, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690002/
https://www.ncbi.nlm.nih.gov/pubmed/26219001
http://dx.doi.org/10.1120/jacmp.v16i4.5358
_version_ 1783279506831704064
author Tang, Xiaoli
Cullip, Tim
Dooley, John
Zagar, Timothy
Jones, Ellen
Chang, Sha
Zhu, Xiaofeng
Lian, Jun
Marks, Lawrence
author_facet Tang, Xiaoli
Cullip, Tim
Dooley, John
Zagar, Timothy
Jones, Ellen
Chang, Sha
Zhu, Xiaofeng
Lian, Jun
Marks, Lawrence
author_sort Tang, Xiaoli
collection PubMed
description Deep inspiration breath‐hold (DIBH) radiotherapy for left‐sided breast cancer can reduce cardiac exposure and internal motion. We modified our in‐house treatment planning system (TPS) to retrospectively analyze breath‐hold motion log files to calculate the dosimetric effect of the motion during breath hold. Thirty left‐sided supine DIBH breast patients treated using AlignRT were studied. Breath‐hold motion was recorded — three translational and three rotational displacements of the treatment surface — the Real Time Deltas (RTD). The corresponding delivered dose was estimated using the beam‐on portions of the RTDs. Each motion was used to calculate dose, and the final estimated dose was the equally weighted average of the multiple resultant doses. Ten of thirty patients had internal mammary nodes (IMN) purposefully included in the tangential fields, and we evaluated the percentage of IMN covered by 40 Gy. The planned and delivered heart mean dose, lungs V20 (volume of the lungs receiving [Formula: see text]), percentage of IMN covered by 40 Gy, and IMN mean dose were compared. The averaged mean and standard deviation of the beam‐on portions of the absolute RTDs were [Formula: see text] , [Formula: see text] , [Formula: see text] , [Formula: see text] , and [Formula: see text] , for vertical, longitudinal, lateral, yaw, roll, and pitch, respectively. The averaged planned and delivered mean heart dose were 99 and 101 cGy. Lungs V20 were 6.59% and 6.74%. IMN 40 Gy coverage was 83% and 77%, and mean IMN dose was 4642 and 4518 cGy. The averaged mean motion during DIBH was smaller than 1 mm and 1°, which reflects the relative reproducibility of the patient breath hold. On average, the mean heart dose and lungs V20 were reasonably close to what have been planned. IMN 40 Gy coverage might be modestly reduced for certain cases. PACS number: 87.55.km, 87.55.N
format Online
Article
Text
id pubmed-5690002
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-56900022018-04-02 Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy Tang, Xiaoli Cullip, Tim Dooley, John Zagar, Timothy Jones, Ellen Chang, Sha Zhu, Xiaofeng Lian, Jun Marks, Lawrence J Appl Clin Med Phys Radiation Oncology Physics Deep inspiration breath‐hold (DIBH) radiotherapy for left‐sided breast cancer can reduce cardiac exposure and internal motion. We modified our in‐house treatment planning system (TPS) to retrospectively analyze breath‐hold motion log files to calculate the dosimetric effect of the motion during breath hold. Thirty left‐sided supine DIBH breast patients treated using AlignRT were studied. Breath‐hold motion was recorded — three translational and three rotational displacements of the treatment surface — the Real Time Deltas (RTD). The corresponding delivered dose was estimated using the beam‐on portions of the RTDs. Each motion was used to calculate dose, and the final estimated dose was the equally weighted average of the multiple resultant doses. Ten of thirty patients had internal mammary nodes (IMN) purposefully included in the tangential fields, and we evaluated the percentage of IMN covered by 40 Gy. The planned and delivered heart mean dose, lungs V20 (volume of the lungs receiving [Formula: see text]), percentage of IMN covered by 40 Gy, and IMN mean dose were compared. The averaged mean and standard deviation of the beam‐on portions of the absolute RTDs were [Formula: see text] , [Formula: see text] , [Formula: see text] , [Formula: see text] , and [Formula: see text] , for vertical, longitudinal, lateral, yaw, roll, and pitch, respectively. The averaged planned and delivered mean heart dose were 99 and 101 cGy. Lungs V20 were 6.59% and 6.74%. IMN 40 Gy coverage was 83% and 77%, and mean IMN dose was 4642 and 4518 cGy. The averaged mean motion during DIBH was smaller than 1 mm and 1°, which reflects the relative reproducibility of the patient breath hold. On average, the mean heart dose and lungs V20 were reasonably close to what have been planned. IMN 40 Gy coverage might be modestly reduced for certain cases. PACS number: 87.55.km, 87.55.N John Wiley and Sons Inc. 2015-07-08 /pmc/articles/PMC5690002/ /pubmed/26219001 http://dx.doi.org/10.1120/jacmp.v16i4.5358 Text en © 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Tang, Xiaoli
Cullip, Tim
Dooley, John
Zagar, Timothy
Jones, Ellen
Chang, Sha
Zhu, Xiaofeng
Lian, Jun
Marks, Lawrence
Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title_full Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title_fullStr Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title_full_unstemmed Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title_short Dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
title_sort dosimetric effect due to the motion during deep inspiration breath hold for left‐sided breast cancer radiotherapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690002/
https://www.ncbi.nlm.nih.gov/pubmed/26219001
http://dx.doi.org/10.1120/jacmp.v16i4.5358
work_keys_str_mv AT tangxiaoli dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT culliptim dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT dooleyjohn dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT zagartimothy dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT jonesellen dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT changsha dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT zhuxiaofeng dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT lianjun dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy
AT markslawrence dosimetriceffectduetothemotionduringdeepinspirationbreathholdforleftsidedbreastcancerradiotherapy