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Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT

In this work, overshoot and undershoot effects associated with step‐and‐shoot IMRT (SSIMRT) delivery on a Varian Clinac 21iX are investigated, and their impact on patient‐specific QA point dose measurements and treatment plan delivery are evaluated. Pinnacle(3) SSIMRT plans consisting of 5, 10, and...

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Autores principales: Baines, John A., Zawlodzka, Sylwia J., Parfitt, Matthew L., Hickey, Brigid E., Pullar, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690035/
https://www.ncbi.nlm.nih.gov/pubmed/27455486
http://dx.doi.org/10.1120/jacmp.v17i4.6129
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author Baines, John A.
Zawlodzka, Sylwia J.
Parfitt, Matthew L.
Hickey, Brigid E.
Pullar, Andrew P.
author_facet Baines, John A.
Zawlodzka, Sylwia J.
Parfitt, Matthew L.
Hickey, Brigid E.
Pullar, Andrew P.
author_sort Baines, John A.
collection PubMed
description In this work, overshoot and undershoot effects associated with step‐and‐shoot IMRT (SSIMRT) delivery on a Varian Clinac 21iX are investigated, and their impact on patient‐specific QA point dose measurements and treatment plan delivery are evaluated. Pinnacle(3) SSIMRT plans consisting of 5, 10, and 15 identical [Formula: see text] MLC defined segments and MU/segment values of 5 MU, 10 MU, and 20 MU were utilized and delivered at 600/300 MU/min. Independent of the number of segments the overshoot and undershoot at 600 MU/min were approximately [Formula: see text] , and [Formula: see text] for 5 MU/segment, 10 MU/segment, and 20 MU/segment, respectively. At 300 MU/min, each of these values is approximately halved. Interfractional variation of these effects (10 fractions), as well as dosimetric variations for intermediate segments, are reduced at the lower dose rate. QA point‐dose measurements for a sample [Formula: see text] of head and neck SSIMRT beams were on average 2.9% (600 MU/min) and 1.7% (300 MU/min) higher than Pinnacle(3) planned doses. In comparison for prostate beams [Formula: see text] , measured point doses were 0.8% (600 MU/min) and 0.4% (300 MU/min) higher. The reduction in planned‐measured point‐dose discrepancies at 300 MU/min can be attributed in part to the inclusion of the first segment (overshoot) in the admixture of segments that deliver measured dose. Pinnacle(3) plans for 10/9 head and neck/prostate treatments were adjusted by [Formula: see text] to include the effects of overshoot and undershoot at 600 MU/min. Comparing original and adjusted plans for each site indicated that the original plan was preferred in 70% and 89% of head and neck and prostate cases, respectively. The disparity between planned and delivered treatment that this suggests can potentially be mitigated by treating SSIMRT at a dose rate below 600 MU/min. PACS number(s): 87.55.Qr, 87.56.bd, 87.56.N‐
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spelling pubmed-56900352018-04-02 Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT Baines, John A. Zawlodzka, Sylwia J. Parfitt, Matthew L. Hickey, Brigid E. Pullar, Andrew P. J Appl Clin Med Phys Radiation Oncology Physics In this work, overshoot and undershoot effects associated with step‐and‐shoot IMRT (SSIMRT) delivery on a Varian Clinac 21iX are investigated, and their impact on patient‐specific QA point dose measurements and treatment plan delivery are evaluated. Pinnacle(3) SSIMRT plans consisting of 5, 10, and 15 identical [Formula: see text] MLC defined segments and MU/segment values of 5 MU, 10 MU, and 20 MU were utilized and delivered at 600/300 MU/min. Independent of the number of segments the overshoot and undershoot at 600 MU/min were approximately [Formula: see text] , and [Formula: see text] for 5 MU/segment, 10 MU/segment, and 20 MU/segment, respectively. At 300 MU/min, each of these values is approximately halved. Interfractional variation of these effects (10 fractions), as well as dosimetric variations for intermediate segments, are reduced at the lower dose rate. QA point‐dose measurements for a sample [Formula: see text] of head and neck SSIMRT beams were on average 2.9% (600 MU/min) and 1.7% (300 MU/min) higher than Pinnacle(3) planned doses. In comparison for prostate beams [Formula: see text] , measured point doses were 0.8% (600 MU/min) and 0.4% (300 MU/min) higher. The reduction in planned‐measured point‐dose discrepancies at 300 MU/min can be attributed in part to the inclusion of the first segment (overshoot) in the admixture of segments that deliver measured dose. Pinnacle(3) plans for 10/9 head and neck/prostate treatments were adjusted by [Formula: see text] to include the effects of overshoot and undershoot at 600 MU/min. Comparing original and adjusted plans for each site indicated that the original plan was preferred in 70% and 89% of head and neck and prostate cases, respectively. The disparity between planned and delivered treatment that this suggests can potentially be mitigated by treating SSIMRT at a dose rate below 600 MU/min. PACS number(s): 87.55.Qr, 87.56.bd, 87.56.N‐ John Wiley and Sons Inc. 2016-07-08 /pmc/articles/PMC5690035/ /pubmed/27455486 http://dx.doi.org/10.1120/jacmp.v17i4.6129 Text en © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Baines, John A.
Zawlodzka, Sylwia J.
Parfitt, Matthew L.
Hickey, Brigid E.
Pullar, Andrew P.
Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title_full Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title_fullStr Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title_full_unstemmed Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title_short Clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot IMRT
title_sort clinical implications of the overshoot effect for treatment plan delivery and patient‐specific quality assurance for step‐and‐shoot imrt
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690035/
https://www.ncbi.nlm.nih.gov/pubmed/27455486
http://dx.doi.org/10.1120/jacmp.v17i4.6129
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