Cargando…
Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff
Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [Formula: see text] ‐capsule must be determined to pr...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690049/ https://www.ncbi.nlm.nih.gov/pubmed/27455475 http://dx.doi.org/10.1120/jacmp.v17i4.5942 |
_version_ | 1783279518110187520 |
---|---|
author | Lützen, Ulf Zhao, Yi Marx, Marlies Imme, Thea Assam, Isong Siebert, Frank‐Andre Culman, Juraj Zuhayra, Maaz |
author_facet | Lützen, Ulf Zhao, Yi Marx, Marlies Imme, Thea Assam, Isong Siebert, Frank‐Andre Culman, Juraj Zuhayra, Maaz |
author_sort | Lützen, Ulf |
collection | PubMed |
description | Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [Formula: see text] ‐capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We describe an alternative method, allowing a considerable reduction of the radiation exposure. Two [Formula: see text] ‐capsules [Formula: see text] were measured multiple times in their own delivery lead containers — that is to say, [Formula: see text] ‐capsules remain inside the containers during the measurements (shielded measurement) using a dose calibrator and a well‐type and a thyroid uptake probe. The results of the shielded measurements were correlated linearly with the [Formula: see text] ‐capsules radioactivity to create calibration curves for the used devices. Additional radioactivity measurements of 50 [Formula: see text] ‐capsules of different radioactivities were done to validate the shielded measuring method. The personal skin dose rate [Formula: see text] was determined using calibrated thermo luminescent dosimeters. The determination coefficients for the calibration curves were [Formula: see text] for all devices. The relative uncertainty of the shielded measurement was [Formula: see text]. At a distance of 10 cm from the unshielded capsule the [Formula: see text] was [Formula: see text] , and on the surface of the lead container containing the [Formula: see text] ‐capsule the [Formula: see text] was 2.99 and [Formula: see text] for the two used container sizes. The calculated reduction of the effective dose by using the shielded measuring method was, depending on the used container size, 74.0% and 97.4%, compared to the measurement of the unshielded [Formula: see text] ‐capsule using a dose calibrator. The measured reduction of the effective radiation dose in the practice was 56.6% and 94.9 for size I and size II containers. The shielded [Formula: see text] ‐capsule measurement reduces the radiation exposure to the staff significantly and offers the same accuracy of the unshielded measurement in the same amount of time. In order to maintain the consistency of the measuring method, monthly tests have to be done by measuring a [Formula: see text] ‐capsule with known radioactivity. PACS number(s): 93.85.Np, 92.20.Td, 87.50.yk, 87.53.Bn |
format | Online Article Text |
id | pubmed-5690049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56900492018-04-02 Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff Lützen, Ulf Zhao, Yi Marx, Marlies Imme, Thea Assam, Isong Siebert, Frank‐Andre Culman, Juraj Zuhayra, Maaz J Appl Clin Med Phys Radiation Oncology Physics Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [Formula: see text] ‐capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We describe an alternative method, allowing a considerable reduction of the radiation exposure. Two [Formula: see text] ‐capsules [Formula: see text] were measured multiple times in their own delivery lead containers — that is to say, [Formula: see text] ‐capsules remain inside the containers during the measurements (shielded measurement) using a dose calibrator and a well‐type and a thyroid uptake probe. The results of the shielded measurements were correlated linearly with the [Formula: see text] ‐capsules radioactivity to create calibration curves for the used devices. Additional radioactivity measurements of 50 [Formula: see text] ‐capsules of different radioactivities were done to validate the shielded measuring method. The personal skin dose rate [Formula: see text] was determined using calibrated thermo luminescent dosimeters. The determination coefficients for the calibration curves were [Formula: see text] for all devices. The relative uncertainty of the shielded measurement was [Formula: see text]. At a distance of 10 cm from the unshielded capsule the [Formula: see text] was [Formula: see text] , and on the surface of the lead container containing the [Formula: see text] ‐capsule the [Formula: see text] was 2.99 and [Formula: see text] for the two used container sizes. The calculated reduction of the effective dose by using the shielded measuring method was, depending on the used container size, 74.0% and 97.4%, compared to the measurement of the unshielded [Formula: see text] ‐capsule using a dose calibrator. The measured reduction of the effective radiation dose in the practice was 56.6% and 94.9 for size I and size II containers. The shielded [Formula: see text] ‐capsule measurement reduces the radiation exposure to the staff significantly and offers the same accuracy of the unshielded measurement in the same amount of time. In order to maintain the consistency of the measuring method, monthly tests have to be done by measuring a [Formula: see text] ‐capsule with known radioactivity. PACS number(s): 93.85.Np, 92.20.Td, 87.50.yk, 87.53.Bn John Wiley and Sons Inc. 2016-07-08 /pmc/articles/PMC5690049/ /pubmed/27455475 http://dx.doi.org/10.1120/jacmp.v17i4.5942 Text en © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Lützen, Ulf Zhao, Yi Marx, Marlies Imme, Thea Assam, Isong Siebert, Frank‐Andre Culman, Juraj Zuhayra, Maaz Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title | Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title_full | Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title_fullStr | Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title_full_unstemmed | Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title_short | Effective method of measuring the radioactivity of [Formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
title_sort | effective method of measuring the radioactivity of [formula: see text] ‐capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690049/ https://www.ncbi.nlm.nih.gov/pubmed/27455475 http://dx.doi.org/10.1120/jacmp.v17i4.5942 |
work_keys_str_mv | AT lutzenulf effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT zhaoyi effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT marxmarlies effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT immethea effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT assamisong effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT siebertfrankandre effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT culmanjuraj effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff AT zuhayramaaz effectivemethodofmeasuringtheradioactivityofformulaseetextcapsulepriortoradioiodinetherapywithsignificantreductionoftheradiationexposuretothemedicalstaff |