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Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer

The purpose of this work is to evaluate the volumetric‐modulated arc therapy (VMAT) multicriteria optimization (MCO) algorithm clinically available in the RayStation treatment planning system (TPS) and its ability to reduce treatment planning time while providing high dosimetric plan quality. Nine p...

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Autores principales: Ghandour, Sarah, Matzinger, Oscar, Pachoud, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690115/
https://www.ncbi.nlm.nih.gov/pubmed/26103500
http://dx.doi.org/10.1120/jacmp.v16i3.5410
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author Ghandour, Sarah
Matzinger, Oscar
Pachoud, Marc
author_facet Ghandour, Sarah
Matzinger, Oscar
Pachoud, Marc
author_sort Ghandour, Sarah
collection PubMed
description The purpose of this work is to evaluate the volumetric‐modulated arc therapy (VMAT) multicriteria optimization (MCO) algorithm clinically available in the RayStation treatment planning system (TPS) and its ability to reduce treatment planning time while providing high dosimetric plan quality. Nine patients with localized prostate cancer who were previously treated with 78 Gy in 39 fractions using VMAT plans and rayArc system based on the direct machine parameter optimization (DMPO) algorithm were selected and replanned using the VMAT‐MCO system. First, the dosimetric quality of the plans was evaluated using multiple conformity metrics that account for target coverage and sparing of healthy tissue, used in our departmental clinical protocols. The conformity and homogeneity index, number of monitor units, and treatment planning time for both modalities were assessed. Next, the effects of the technical plan parameters, such as constraint leaf motion CLM [Formula: see text] and maximum arc delivery time T (s), on the accuracy of delivered dose were evaluated using quality assurance passing rates (QAs) measured using the Delta(4) phantom from ScandiDos. For the dosimetric plan's quality analysis, the results show that the VMAT‐MCO system provides plans comparable to the rayArc system with no statistical difference for V95% ([Formula: see text]), D1% ([Formula: see text]), CI ([Formula: see text]), and HI ([Formula: see text]) of the PTV, bladder ([Formula: see text]), and rectum ([Formula: see text]) constraints, except for the femoral heads and healthy tissues, for which a dose reduction was observed using MCO compared with rayArc ([Formula: see text]). The technical parameter study showed that a combination of CLM equal to [Formula: see text] and a maximum delivery time of 72 s allowed the accurate delivery of the VMAT‐MCO plan on the Elekta Versa HD linear accelerator. Planning evaluation and dosimetric measurements showed that VMAT‐MCO can be used clinically with the advantage of enhanced planning process efficiency by reducing the treatment planning time without impairing dosimetric quality. PACS numbers: 87.55.D, 87.55.de, 87.55.Qr
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spelling pubmed-56901152018-04-02 Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer Ghandour, Sarah Matzinger, Oscar Pachoud, Marc J Appl Clin Med Phys Radiation Oncology Physics The purpose of this work is to evaluate the volumetric‐modulated arc therapy (VMAT) multicriteria optimization (MCO) algorithm clinically available in the RayStation treatment planning system (TPS) and its ability to reduce treatment planning time while providing high dosimetric plan quality. Nine patients with localized prostate cancer who were previously treated with 78 Gy in 39 fractions using VMAT plans and rayArc system based on the direct machine parameter optimization (DMPO) algorithm were selected and replanned using the VMAT‐MCO system. First, the dosimetric quality of the plans was evaluated using multiple conformity metrics that account for target coverage and sparing of healthy tissue, used in our departmental clinical protocols. The conformity and homogeneity index, number of monitor units, and treatment planning time for both modalities were assessed. Next, the effects of the technical plan parameters, such as constraint leaf motion CLM [Formula: see text] and maximum arc delivery time T (s), on the accuracy of delivered dose were evaluated using quality assurance passing rates (QAs) measured using the Delta(4) phantom from ScandiDos. For the dosimetric plan's quality analysis, the results show that the VMAT‐MCO system provides plans comparable to the rayArc system with no statistical difference for V95% ([Formula: see text]), D1% ([Formula: see text]), CI ([Formula: see text]), and HI ([Formula: see text]) of the PTV, bladder ([Formula: see text]), and rectum ([Formula: see text]) constraints, except for the femoral heads and healthy tissues, for which a dose reduction was observed using MCO compared with rayArc ([Formula: see text]). The technical parameter study showed that a combination of CLM equal to [Formula: see text] and a maximum delivery time of 72 s allowed the accurate delivery of the VMAT‐MCO plan on the Elekta Versa HD linear accelerator. Planning evaluation and dosimetric measurements showed that VMAT‐MCO can be used clinically with the advantage of enhanced planning process efficiency by reducing the treatment planning time without impairing dosimetric quality. PACS numbers: 87.55.D, 87.55.de, 87.55.Qr John Wiley and Sons Inc. 2015-05-08 /pmc/articles/PMC5690115/ /pubmed/26103500 http://dx.doi.org/10.1120/jacmp.v16i3.5410 Text en © 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Ghandour, Sarah
Matzinger, Oscar
Pachoud, Marc
Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title_full Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title_fullStr Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title_full_unstemmed Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title_short Volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
title_sort volumetric‐modulated arc therapy planning using multicriteria optimization for localized prostate cancer
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690115/
https://www.ncbi.nlm.nih.gov/pubmed/26103500
http://dx.doi.org/10.1120/jacmp.v16i3.5410
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