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Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study
Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, me...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690294/ https://www.ncbi.nlm.nih.gov/pubmed/28858986 http://dx.doi.org/10.1097/j.pain.0000000000001034 |
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author | Raputova, Jana Srotova, Iva Vlckova, Eva Sommer, Claudia Üçeyler, Nurcan Birklein, Frank Rittner, Heike L. Rebhorn, Cora Adamova, Blanka Kovalova, Ivana Kralickova Nekvapilova, Eva Forer, Lucas Belobradkova, Jana Olsovsky, Jindrich Weber, Pavel Dusek, Ladislav Jarkovsky, Jiri Bednarik, Josef |
author_facet | Raputova, Jana Srotova, Iva Vlckova, Eva Sommer, Claudia Üçeyler, Nurcan Birklein, Frank Rittner, Heike L. Rebhorn, Cora Adamova, Blanka Kovalova, Ivana Kralickova Nekvapilova, Eva Forer, Lucas Belobradkova, Jana Olsovsky, Jindrich Weber, Pavel Dusek, Ladislav Jarkovsky, Jiri Bednarik, Josef |
author_sort | Raputova, Jana |
collection | PubMed |
description | Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. All parameters were analyzed with regard to the presence and severity of neuropathic pain. Neuropathic pain was positively correlated with the severity of neuropathy and thermal hyposensitivity (P < 0.001). A minority of patients with painful DSPN (14.6%) had a sensory profile, indicating thermal hypersensitivity that was associated with less severe neuropathy. Neuropathic pain was further linked to female sex and higher cognitive appraisal of pain as assessed by the pain catastrophizing scale (P < 0.001), while parameters related to diabetes showed no influence on neuropathic pain with the exception of laboratory signs of nephropathy. This study confirms the value of comprehensive DSPN phenotyping and underlines the importance of the severity of neuropathy for the presence of pain. Different sensory phenotypes might be useful for stratification of patients with painful DSPN for analgesic treatment and drug trials. |
format | Online Article Text |
id | pubmed-5690294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-56902942017-11-29 Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study Raputova, Jana Srotova, Iva Vlckova, Eva Sommer, Claudia Üçeyler, Nurcan Birklein, Frank Rittner, Heike L. Rebhorn, Cora Adamova, Blanka Kovalova, Ivana Kralickova Nekvapilova, Eva Forer, Lucas Belobradkova, Jana Olsovsky, Jindrich Weber, Pavel Dusek, Ladislav Jarkovsky, Jiri Bednarik, Josef Pain Research Paper Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. All parameters were analyzed with regard to the presence and severity of neuropathic pain. Neuropathic pain was positively correlated with the severity of neuropathy and thermal hyposensitivity (P < 0.001). A minority of patients with painful DSPN (14.6%) had a sensory profile, indicating thermal hypersensitivity that was associated with less severe neuropathy. Neuropathic pain was further linked to female sex and higher cognitive appraisal of pain as assessed by the pain catastrophizing scale (P < 0.001), while parameters related to diabetes showed no influence on neuropathic pain with the exception of laboratory signs of nephropathy. This study confirms the value of comprehensive DSPN phenotyping and underlines the importance of the severity of neuropathy for the presence of pain. Different sensory phenotypes might be useful for stratification of patients with painful DSPN for analgesic treatment and drug trials. Wolters Kluwer 2017-08-03 2017-12 /pmc/articles/PMC5690294/ /pubmed/28858986 http://dx.doi.org/10.1097/j.pain.0000000000001034 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Research Paper Raputova, Jana Srotova, Iva Vlckova, Eva Sommer, Claudia Üçeyler, Nurcan Birklein, Frank Rittner, Heike L. Rebhorn, Cora Adamova, Blanka Kovalova, Ivana Kralickova Nekvapilova, Eva Forer, Lucas Belobradkova, Jana Olsovsky, Jindrich Weber, Pavel Dusek, Ladislav Jarkovsky, Jiri Bednarik, Josef Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title | Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title_full | Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title_fullStr | Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title_full_unstemmed | Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title_short | Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
title_sort | sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690294/ https://www.ncbi.nlm.nih.gov/pubmed/28858986 http://dx.doi.org/10.1097/j.pain.0000000000001034 |
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