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Lessons learned from continued TB outbreaks in a high school
We investigated the aftereffects of confirmatory QuantiFERON testing (QFT) added to a positive tuberculin skin test (TST). We reviewed the pre and post course of sequential tuberculosis (TB) outbreaks in a high school where massive 43 active TB cases had been found within one year before delayed con...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690470/ https://www.ncbi.nlm.nih.gov/pubmed/29145443 http://dx.doi.org/10.1371/journal.pone.0188076 |
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author | Kim, Young Kim, Byeong Ki Choi, Hong Jo Ryu, Sung Weon Kim, Eui Sook Chang, Yoon Soo Kim, Hee Jin Cha, Jae Hyung Kim, Je Hyeong Shin, Chol Lee, Seung Heon |
author_facet | Kim, Young Kim, Byeong Ki Choi, Hong Jo Ryu, Sung Weon Kim, Eui Sook Chang, Yoon Soo Kim, Hee Jin Cha, Jae Hyung Kim, Je Hyeong Shin, Chol Lee, Seung Heon |
author_sort | Kim, Young |
collection | PubMed |
description | We investigated the aftereffects of confirmatory QuantiFERON testing (QFT) added to a positive tuberculin skin test (TST). We reviewed the pre and post course of sequential tuberculosis (TB) outbreaks in a high school where massive 43 active TB cases had been found within one year before delayed contact investigation. And we investigated the TB development in relation to initial TST and QFT during mean follow-up of 3.9 ± 0.9 years. After delayed contact investigation for two subsequent TB outbreaks, 925 contacts were divided into the following 3 groups: TST- (n = 632), TST+/QFT+ (n = 24), TST+/QFT- (n = 258). QFT- was more prevalent than QFT+ in contacts with 10mm ≤ TST <15mm (158, 61.2%) compared with TST ≥15mm (100, 38.8%) among the TST+ reactors (P < 0.001). Among the 258 TST+/QFT- subjects, 256 received no latent TB infection (LTBI) treatment, but 7 contacts developed TB during follow-up. Among these 7 patients, 4 had initial TST ≥15mm and 3 had 10mm ≤ TST <15mm. In conclusion, the delayed contact investigation for LTBI in a high school resulted in continued TB developments. False-negative QFT performed late among the TST+ reactors should not be considered criteria for LTBI treatment. Additionally, the contacts only with TST ≥15mm should be considered for LTBI treatment in congregate settings of intermediate-burden countries. |
format | Online Article Text |
id | pubmed-5690470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56904702017-11-30 Lessons learned from continued TB outbreaks in a high school Kim, Young Kim, Byeong Ki Choi, Hong Jo Ryu, Sung Weon Kim, Eui Sook Chang, Yoon Soo Kim, Hee Jin Cha, Jae Hyung Kim, Je Hyeong Shin, Chol Lee, Seung Heon PLoS One Research Article We investigated the aftereffects of confirmatory QuantiFERON testing (QFT) added to a positive tuberculin skin test (TST). We reviewed the pre and post course of sequential tuberculosis (TB) outbreaks in a high school where massive 43 active TB cases had been found within one year before delayed contact investigation. And we investigated the TB development in relation to initial TST and QFT during mean follow-up of 3.9 ± 0.9 years. After delayed contact investigation for two subsequent TB outbreaks, 925 contacts were divided into the following 3 groups: TST- (n = 632), TST+/QFT+ (n = 24), TST+/QFT- (n = 258). QFT- was more prevalent than QFT+ in contacts with 10mm ≤ TST <15mm (158, 61.2%) compared with TST ≥15mm (100, 38.8%) among the TST+ reactors (P < 0.001). Among the 258 TST+/QFT- subjects, 256 received no latent TB infection (LTBI) treatment, but 7 contacts developed TB during follow-up. Among these 7 patients, 4 had initial TST ≥15mm and 3 had 10mm ≤ TST <15mm. In conclusion, the delayed contact investigation for LTBI in a high school resulted in continued TB developments. False-negative QFT performed late among the TST+ reactors should not be considered criteria for LTBI treatment. Additionally, the contacts only with TST ≥15mm should be considered for LTBI treatment in congregate settings of intermediate-burden countries. Public Library of Science 2017-11-16 /pmc/articles/PMC5690470/ /pubmed/29145443 http://dx.doi.org/10.1371/journal.pone.0188076 Text en © 2017 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Young Kim, Byeong Ki Choi, Hong Jo Ryu, Sung Weon Kim, Eui Sook Chang, Yoon Soo Kim, Hee Jin Cha, Jae Hyung Kim, Je Hyeong Shin, Chol Lee, Seung Heon Lessons learned from continued TB outbreaks in a high school |
title | Lessons learned from continued TB outbreaks in a high school |
title_full | Lessons learned from continued TB outbreaks in a high school |
title_fullStr | Lessons learned from continued TB outbreaks in a high school |
title_full_unstemmed | Lessons learned from continued TB outbreaks in a high school |
title_short | Lessons learned from continued TB outbreaks in a high school |
title_sort | lessons learned from continued tb outbreaks in a high school |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690470/ https://www.ncbi.nlm.nih.gov/pubmed/29145443 http://dx.doi.org/10.1371/journal.pone.0188076 |
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