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A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes

The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using...

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Autores principales: Siavashpour, Zahra, Aghamiri, Mahmoud Reza, Jaberi, Ramin, ZareAkha, Naser, Manshadi, Hamid Reza Dehghan, Kirisits, Christian, Sedaghat, Mahbod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690927/
https://www.ncbi.nlm.nih.gov/pubmed/27167253
http://dx.doi.org/10.1120/jacmp.v17i3.5584
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author Siavashpour, Zahra
Aghamiri, Mahmoud Reza
Jaberi, Ramin
ZareAkha, Naser
Manshadi, Hamid Reza Dehghan
Kirisits, Christian
Sedaghat, Mahbod
author_facet Siavashpour, Zahra
Aghamiri, Mahmoud Reza
Jaberi, Ramin
ZareAkha, Naser
Manshadi, Hamid Reza Dehghan
Kirisits, Christian
Sedaghat, Mahbod
author_sort Siavashpour, Zahra
collection PubMed
description The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using Rotterdam applicators. The patients were CT scanned twice with empty and full bladder. Two treatment plans were prepared on each of the image sets. Patients were categorized into two groups; those treated with a tandem length of 4 cm or smaller [Formula: see text] and those with tandem length larger than 4 cm ([Formula: see text]). Only one tandem tip angle of 30° was studied. Dose‐volume histograms (DVHs) of OARs were calculated and compared. Bladder dose was significantly affected by both bladder volume and tandem physical length for [Formula: see text]. This was reflected on the values obtained for [Formula: see text] , [Formula: see text] , and [Formula: see text] for both empty and full bladder cases. When [Formula: see text] , no correlation could be established between variations in bladder dose and bladder volume. Rectum dose was generally lower when the bladder was empty and [Formula: see text]. Dose to sigmoid was increased when [Formula: see text]; this increase was larger when the bladder was full. Our results suggest that, for tandems longer than 4 cm, keeping the bladder empty may reduce the dose to rectum and sigmoid. This is contrary to cases where a shorter than 4 cm tandem is used in which a full bladder (about 50–120 cm(3)) tends to result in a lower dose to rectum and sigmoid. Attention should be given to doses to sigmoid with long tandem lengths, as a larger tandem generally results in a larger dose to sigmoid. PACS number(s): 87.53.Jw
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spelling pubmed-56909272018-04-02 A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes Siavashpour, Zahra Aghamiri, Mahmoud Reza Jaberi, Ramin ZareAkha, Naser Manshadi, Hamid Reza Dehghan Kirisits, Christian Sedaghat, Mahbod J Appl Clin Med Phys Radiation Oncology Physics The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using Rotterdam applicators. The patients were CT scanned twice with empty and full bladder. Two treatment plans were prepared on each of the image sets. Patients were categorized into two groups; those treated with a tandem length of 4 cm or smaller [Formula: see text] and those with tandem length larger than 4 cm ([Formula: see text]). Only one tandem tip angle of 30° was studied. Dose‐volume histograms (DVHs) of OARs were calculated and compared. Bladder dose was significantly affected by both bladder volume and tandem physical length for [Formula: see text]. This was reflected on the values obtained for [Formula: see text] , [Formula: see text] , and [Formula: see text] for both empty and full bladder cases. When [Formula: see text] , no correlation could be established between variations in bladder dose and bladder volume. Rectum dose was generally lower when the bladder was empty and [Formula: see text]. Dose to sigmoid was increased when [Formula: see text]; this increase was larger when the bladder was full. Our results suggest that, for tandems longer than 4 cm, keeping the bladder empty may reduce the dose to rectum and sigmoid. This is contrary to cases where a shorter than 4 cm tandem is used in which a full bladder (about 50–120 cm(3)) tends to result in a lower dose to rectum and sigmoid. Attention should be given to doses to sigmoid with long tandem lengths, as a larger tandem generally results in a larger dose to sigmoid. PACS number(s): 87.53.Jw John Wiley and Sons Inc. 2016-05-08 /pmc/articles/PMC5690927/ /pubmed/27167253 http://dx.doi.org/10.1120/jacmp.v17i3.5584 Text en © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Siavashpour, Zahra
Aghamiri, Mahmoud Reza
Jaberi, Ramin
ZareAkha, Naser
Manshadi, Hamid Reza Dehghan
Kirisits, Christian
Sedaghat, Mahbod
A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title_full A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title_fullStr A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title_full_unstemmed A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title_short A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
title_sort comparison of organs at risk doses in gyn intracavitary brachytherapy for different tandem lengths and bladder volumes
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690927/
https://www.ncbi.nlm.nih.gov/pubmed/27167253
http://dx.doi.org/10.1120/jacmp.v17i3.5584
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