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Jaw position uncertainty and adjacent fields in breast cancer radiotherapy

Locoregional treatment of breast cancer involves adjacent, half blocked fields matched at isocenter. The objective of this work is to study the dosimetric effects of the uncertainties in jaw positioning for such a case, and how a treatment planning protocol including adjacent field overlap of 1 mm a...

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Autores principales: Hedin, Emma, Bäck, Anna, Chakarova, Roumiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691020/
https://www.ncbi.nlm.nih.gov/pubmed/26699579
http://dx.doi.org/10.1120/jacmp.v16i6.5673
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author Hedin, Emma
Bäck, Anna
Chakarova, Roumiana
author_facet Hedin, Emma
Bäck, Anna
Chakarova, Roumiana
author_sort Hedin, Emma
collection PubMed
description Locoregional treatment of breast cancer involves adjacent, half blocked fields matched at isocenter. The objective of this work is to study the dosimetric effects of the uncertainties in jaw positioning for such a case, and how a treatment planning protocol including adjacent field overlap of 1 mm affects the dose distribution. A representative treatment plan, involving 6 and 15 photon beams, for a patient treated at our hospital is chosen. Monte Carlo method (EGSnrc/BEAMnrc) is used to simulate the treatment. Uncertainties in jaw positioning of [Formula: see text] are addressed, which implies extremes in reality of 2 mm field gap/overlap when planning adjacent fields without overlap and 1 mm gap or 3 mm overlap for a planning protocol with 1 mm overlap. Dosimetric parameters for PTV, lung and body are analyzed. Treatment planning protocol with 1 mm overlap of the adjacent fields does not considerably counteract possible underdosage of the target in the case studied. [Formula: see text] is for example reduced from 95% for perfectly aligned fields to 90% and 91% for 2 mm and 1 mm gap, respectively. However, the risk of overdosage in PTV and in healthy soft tissue is increased when following the protocol with 1 mm overlap. A 3 mm overlap compared to 2 mm overlap results in an increase in maximum dose to PTV, [Formula: see text] , from 113% to 121%. [Formula: see text] for ‘Body‐PTV’ is also increased from [Formula: see text] to [Formula: see text]. A treatment planning protocol with 1 mm overlap does not considerably improve the coverage of PTV in the case of erroneous jaw positions causing gap between fields, but increases the overdosage in PTV and doses to healthy tissue, in the case of overlapping fields, for the case investigated. PACS numbers: 87.55.D‐, 87.55.dk, 87.55.Gh, 87.55.K‐, 87.56.J‐
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spelling pubmed-56910202018-04-02 Jaw position uncertainty and adjacent fields in breast cancer radiotherapy Hedin, Emma Bäck, Anna Chakarova, Roumiana J Appl Clin Med Phys Radiation Oncology Physics Locoregional treatment of breast cancer involves adjacent, half blocked fields matched at isocenter. The objective of this work is to study the dosimetric effects of the uncertainties in jaw positioning for such a case, and how a treatment planning protocol including adjacent field overlap of 1 mm affects the dose distribution. A representative treatment plan, involving 6 and 15 photon beams, for a patient treated at our hospital is chosen. Monte Carlo method (EGSnrc/BEAMnrc) is used to simulate the treatment. Uncertainties in jaw positioning of [Formula: see text] are addressed, which implies extremes in reality of 2 mm field gap/overlap when planning adjacent fields without overlap and 1 mm gap or 3 mm overlap for a planning protocol with 1 mm overlap. Dosimetric parameters for PTV, lung and body are analyzed. Treatment planning protocol with 1 mm overlap of the adjacent fields does not considerably counteract possible underdosage of the target in the case studied. [Formula: see text] is for example reduced from 95% for perfectly aligned fields to 90% and 91% for 2 mm and 1 mm gap, respectively. However, the risk of overdosage in PTV and in healthy soft tissue is increased when following the protocol with 1 mm overlap. A 3 mm overlap compared to 2 mm overlap results in an increase in maximum dose to PTV, [Formula: see text] , from 113% to 121%. [Formula: see text] for ‘Body‐PTV’ is also increased from [Formula: see text] to [Formula: see text]. A treatment planning protocol with 1 mm overlap does not considerably improve the coverage of PTV in the case of erroneous jaw positions causing gap between fields, but increases the overdosage in PTV and doses to healthy tissue, in the case of overlapping fields, for the case investigated. PACS numbers: 87.55.D‐, 87.55.dk, 87.55.Gh, 87.55.K‐, 87.56.J‐ John Wiley and Sons Inc. 2015-11-08 /pmc/articles/PMC5691020/ /pubmed/26699579 http://dx.doi.org/10.1120/jacmp.v16i6.5673 Text en © 2015 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Hedin, Emma
Bäck, Anna
Chakarova, Roumiana
Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title_full Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title_fullStr Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title_full_unstemmed Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title_short Jaw position uncertainty and adjacent fields in breast cancer radiotherapy
title_sort jaw position uncertainty and adjacent fields in breast cancer radiotherapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691020/
https://www.ncbi.nlm.nih.gov/pubmed/26699579
http://dx.doi.org/10.1120/jacmp.v16i6.5673
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