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Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses

Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as tr...

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Autores principales: Cruz-Adalia, Aránzazu, Ramirez-Santiago, Guillermo, Osuna-Pérez, Jesús, Torres-Torresano, Mónica, Zorita, Virgina, Martínez-Riaño, Ana, Boccasavia, Viola, Borroto, Aldo, Martínez del Hoyo, Gloria, González-Granado, José María, Alarcón, Balbino, Sánchez-Madrid, Francisco, Veiga, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691066/
https://www.ncbi.nlm.nih.gov/pubmed/29147022
http://dx.doi.org/10.1038/s41467-017-01661-7
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author Cruz-Adalia, Aránzazu
Ramirez-Santiago, Guillermo
Osuna-Pérez, Jesús
Torres-Torresano, Mónica
Zorita, Virgina
Martínez-Riaño, Ana
Boccasavia, Viola
Borroto, Aldo
Martínez del Hoyo, Gloria
González-Granado, José María
Alarcón, Balbino
Sánchez-Madrid, Francisco
Veiga, Esteban
author_facet Cruz-Adalia, Aránzazu
Ramirez-Santiago, Guillermo
Osuna-Pérez, Jesús
Torres-Torresano, Mónica
Zorita, Virgina
Martínez-Riaño, Ana
Boccasavia, Viola
Borroto, Aldo
Martínez del Hoyo, Gloria
González-Granado, José María
Alarcón, Balbino
Sánchez-Madrid, Francisco
Veiga, Esteban
author_sort Cruz-Adalia, Aránzazu
collection PubMed
description Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8(+) T cells, which proliferate and become cytotoxic in response. CD4(+) T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8(+) T cells with low PD-1 expression. Moreover, transphagocytic CD4(+) T cells induce protective anti-tumour immune responses by priming CD8(+) T cells, highlighting the potential of CD4(+) T cells as a tool for cancer immunotherapy.
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spelling pubmed-56910662017-11-20 Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses Cruz-Adalia, Aránzazu Ramirez-Santiago, Guillermo Osuna-Pérez, Jesús Torres-Torresano, Mónica Zorita, Virgina Martínez-Riaño, Ana Boccasavia, Viola Borroto, Aldo Martínez del Hoyo, Gloria González-Granado, José María Alarcón, Balbino Sánchez-Madrid, Francisco Veiga, Esteban Nat Commun Article Bacterial phagocytosis and antigen cross-presentation to activate CD8(+) T cells are principal functions of professional antigen presenting cells. However, conventional CD4(+) T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8(+) T cells, which proliferate and become cytotoxic in response. CD4(+) T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8(+) T cells with low PD-1 expression. Moreover, transphagocytic CD4(+) T cells induce protective anti-tumour immune responses by priming CD8(+) T cells, highlighting the potential of CD4(+) T cells as a tool for cancer immunotherapy. Nature Publishing Group UK 2017-11-17 /pmc/articles/PMC5691066/ /pubmed/29147022 http://dx.doi.org/10.1038/s41467-017-01661-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cruz-Adalia, Aránzazu
Ramirez-Santiago, Guillermo
Osuna-Pérez, Jesús
Torres-Torresano, Mónica
Zorita, Virgina
Martínez-Riaño, Ana
Boccasavia, Viola
Borroto, Aldo
Martínez del Hoyo, Gloria
González-Granado, José María
Alarcón, Balbino
Sánchez-Madrid, Francisco
Veiga, Esteban
Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title_full Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title_fullStr Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title_full_unstemmed Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title_short Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses
title_sort conventional cd4(+) t cells present bacterial antigens to induce cytotoxic and memory cd8(+) t cell responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691066/
https://www.ncbi.nlm.nih.gov/pubmed/29147022
http://dx.doi.org/10.1038/s41467-017-01661-7
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