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Beneficial effects of oral pure caffeine on oxidative stress

Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols a...

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Autores principales: Metro, Daniela, Cernaro, Valeria, Santoro, Domenico, Papa, Mattia, Buemi, Michele, Benvenga, Salvatore, Manasseri, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691215/
https://www.ncbi.nlm.nih.gov/pubmed/29204368
http://dx.doi.org/10.1016/j.jcte.2017.10.001
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author Metro, Daniela
Cernaro, Valeria
Santoro, Domenico
Papa, Mattia
Buemi, Michele
Benvenga, Salvatore
Manasseri, Luigi
author_facet Metro, Daniela
Cernaro, Valeria
Santoro, Domenico
Papa, Mattia
Buemi, Michele
Benvenga, Salvatore
Manasseri, Luigi
author_sort Metro, Daniela
collection PubMed
description Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary. To assess whether caffeine per se could account for antioxidant properties of coffee in the short-term, we tested the ability of pure caffeine ingestion (5 mg/kg body weight/day in two daily doses for seven consecutive days) to improve plasma levels of six biochemical indices in healthy male volunteers (n = 15). These indices were total antioxidant capacity (TAC), glutathione (GSH), oxidized glutathione (GSSG), GSH to GSSG ratio, lipid hydroperoxides (LOOH) and malondialdehyde (MDA). We found that all indices changed significantly (P < .05 or < .01) in a favourable manner, ranging from −41% for GSSG to −70% for LHP levels, and +106% for GSH levels to +249% for the GSG/GSSG ratio. Changes of any given index were uniform across subjects, with no outliers. We conclude that caffeine has unequivocal, consistent antioxidant properties.
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spelling pubmed-56912152017-12-04 Beneficial effects of oral pure caffeine on oxidative stress Metro, Daniela Cernaro, Valeria Santoro, Domenico Papa, Mattia Buemi, Michele Benvenga, Salvatore Manasseri, Luigi J Clin Transl Endocrinol Research Paper Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary. To assess whether caffeine per se could account for antioxidant properties of coffee in the short-term, we tested the ability of pure caffeine ingestion (5 mg/kg body weight/day in two daily doses for seven consecutive days) to improve plasma levels of six biochemical indices in healthy male volunteers (n = 15). These indices were total antioxidant capacity (TAC), glutathione (GSH), oxidized glutathione (GSSG), GSH to GSSG ratio, lipid hydroperoxides (LOOH) and malondialdehyde (MDA). We found that all indices changed significantly (P < .05 or < .01) in a favourable manner, ranging from −41% for GSSG to −70% for LHP levels, and +106% for GSH levels to +249% for the GSG/GSSG ratio. Changes of any given index were uniform across subjects, with no outliers. We conclude that caffeine has unequivocal, consistent antioxidant properties. Elsevier 2017-10-13 /pmc/articles/PMC5691215/ /pubmed/29204368 http://dx.doi.org/10.1016/j.jcte.2017.10.001 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Metro, Daniela
Cernaro, Valeria
Santoro, Domenico
Papa, Mattia
Buemi, Michele
Benvenga, Salvatore
Manasseri, Luigi
Beneficial effects of oral pure caffeine on oxidative stress
title Beneficial effects of oral pure caffeine on oxidative stress
title_full Beneficial effects of oral pure caffeine on oxidative stress
title_fullStr Beneficial effects of oral pure caffeine on oxidative stress
title_full_unstemmed Beneficial effects of oral pure caffeine on oxidative stress
title_short Beneficial effects of oral pure caffeine on oxidative stress
title_sort beneficial effects of oral pure caffeine on oxidative stress
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691215/
https://www.ncbi.nlm.nih.gov/pubmed/29204368
http://dx.doi.org/10.1016/j.jcte.2017.10.001
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