Cargando…

Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria

BACKGROUND: The purpose of this study was to evaluate the ability of poor ovarian response criteria to classify women presenting with infertility and oligomenorrhea as having “occult” premature ovarian insufficiency. METHODS: This was a cross sectional study conducted at Aziz Medical Center, Karachi...

Descripción completa

Detalles Bibliográficos
Autores principales: Izhar, Rubina, Husain, Samia, Tahir, Suhaima, Husain, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691252/
https://www.ncbi.nlm.nih.gov/pubmed/29201666
_version_ 1783279758237237248
author Izhar, Rubina
Husain, Samia
Tahir, Suhaima
Husain, Sonia
author_facet Izhar, Rubina
Husain, Samia
Tahir, Suhaima
Husain, Sonia
author_sort Izhar, Rubina
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the ability of poor ovarian response criteria to classify women presenting with infertility and oligomenorrhea as having “occult” premature ovarian insufficiency. METHODS: This was a cross sectional study conducted at Aziz Medical Center, Karachi, Pakistan from 1st August 2015 to 31st July 2016. Women with infertility and oligomenorrhea were included. All eligible women underwent day 2 FSH level and an early follicular phase transvaginal ultrasound to assess the antral follicular count (AFC). All women then underwent the confirmatory test, of Anti-Mullerian Hormone (AMH) level. The main outcome measure was assignment to occult premature ovarian insufficiency (POI) after screening that used the criteria set out in fertility guideline for predicting the likely ovarian response to gonadotrophin stimulation. Another measure was to compare the sensitivity and specificity of the two index criteria, of FSH and AFC, relative to the emerging reference standard, of the AMH criterion. RESULTS: The three criteria together classified 59 (34.91%) women as occult POI in those with oligomenorrhea. The sensitivity, specificity, negative predictive value and positive predictive value of FSH relative to AMH for these women were 77.8%, 95.7%, 90.2% and 89.4%, respectively whereas the same values of AFC relative to AMH were 92.6%, 99.1 %, 96.6% and 98%, respectively. CONCLUSION: Women with menstrual irregularity and infertility are at a higher risk for satisfying criteria of poor ovarian response irrespective of age. A policy incorporating these surrogate markers can be used to screen these women for occult premature ovarian insufficiency.
format Online
Article
Text
id pubmed-5691252
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Avicenna Research Institute
record_format MEDLINE/PubMed
spelling pubmed-56912522017-12-01 Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria Izhar, Rubina Husain, Samia Tahir, Suhaima Husain, Sonia J Reprod Infertil Original Article BACKGROUND: The purpose of this study was to evaluate the ability of poor ovarian response criteria to classify women presenting with infertility and oligomenorrhea as having “occult” premature ovarian insufficiency. METHODS: This was a cross sectional study conducted at Aziz Medical Center, Karachi, Pakistan from 1st August 2015 to 31st July 2016. Women with infertility and oligomenorrhea were included. All eligible women underwent day 2 FSH level and an early follicular phase transvaginal ultrasound to assess the antral follicular count (AFC). All women then underwent the confirmatory test, of Anti-Mullerian Hormone (AMH) level. The main outcome measure was assignment to occult premature ovarian insufficiency (POI) after screening that used the criteria set out in fertility guideline for predicting the likely ovarian response to gonadotrophin stimulation. Another measure was to compare the sensitivity and specificity of the two index criteria, of FSH and AFC, relative to the emerging reference standard, of the AMH criterion. RESULTS: The three criteria together classified 59 (34.91%) women as occult POI in those with oligomenorrhea. The sensitivity, specificity, negative predictive value and positive predictive value of FSH relative to AMH for these women were 77.8%, 95.7%, 90.2% and 89.4%, respectively whereas the same values of AFC relative to AMH were 92.6%, 99.1 %, 96.6% and 98%, respectively. CONCLUSION: Women with menstrual irregularity and infertility are at a higher risk for satisfying criteria of poor ovarian response irrespective of age. A policy incorporating these surrogate markers can be used to screen these women for occult premature ovarian insufficiency. Avicenna Research Institute 2017 /pmc/articles/PMC5691252/ /pubmed/29201666 Text en Copyright© 2017, Avicenna Research Institute. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Izhar, Rubina
Husain, Samia
Tahir, Suhaima
Husain, Sonia
Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title_full Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title_fullStr Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title_full_unstemmed Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title_short Occult Form of Premature Ovarian Insufficiency in Women with Infertility and Oligomenorrhea as Assessed by Poor Ovarian Response Criteria
title_sort occult form of premature ovarian insufficiency in women with infertility and oligomenorrhea as assessed by poor ovarian response criteria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691252/
https://www.ncbi.nlm.nih.gov/pubmed/29201666
work_keys_str_mv AT izharrubina occultformofprematureovarianinsufficiencyinwomenwithinfertilityandoligomenorrheaasassessedbypoorovarianresponsecriteria
AT husainsamia occultformofprematureovarianinsufficiencyinwomenwithinfertilityandoligomenorrheaasassessedbypoorovarianresponsecriteria
AT tahirsuhaima occultformofprematureovarianinsufficiencyinwomenwithinfertilityandoligomenorrheaasassessedbypoorovarianresponsecriteria
AT husainsonia occultformofprematureovarianinsufficiencyinwomenwithinfertilityandoligomenorrheaasassessedbypoorovarianresponsecriteria