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Molecular ensembles make evolution unpredictable
Evolutionary prediction is of deep practical and philosophical importance. Here we show, using a simple computational protein model, that protein evolution remains unpredictable, even if one knows the effects of all mutations in an ancestral protein background. We performed a virtual deep mutational...
Autores principales: | Sailer, Zachary R., Harms, Michael J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691298/ https://www.ncbi.nlm.nih.gov/pubmed/29078365 http://dx.doi.org/10.1073/pnas.1711927114 |
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