ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β(1) pathway

BACKGROUND: Growing evidence indicates that oxidative stress (OS) plays a pivotal role in Diabetic nephropathy (DN). In a previous study we demonstrated that ALA/LA protected HK-2 cells against high glucose-induced cytotoxicity. So we aimed to establish the glucose injury model of HK-2 cells and inv...

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Detalles Bibliográficos
Autores principales: Jiang, Mingxia, Zhang, Haifen, Zhai, Lijie, Ye, Bianliang, Cheng, Yin, Zhai, Chengkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691398/
https://www.ncbi.nlm.nih.gov/pubmed/29145851
http://dx.doi.org/10.1186/s12944-017-0611-6

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