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Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle
Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691622/ https://www.ncbi.nlm.nih.gov/pubmed/28946621 http://dx.doi.org/10.3390/v9100270 |
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author | Leymarie, Olivier Lepont, Leslie Berlioz-Torrent, Clarisse |
author_facet | Leymarie, Olivier Lepont, Leslie Berlioz-Torrent, Clarisse |
author_sort | Leymarie, Olivier |
collection | PubMed |
description | Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response. |
format | Online Article Text |
id | pubmed-5691622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56916222017-11-22 Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle Leymarie, Olivier Lepont, Leslie Berlioz-Torrent, Clarisse Viruses Review Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response. MDPI 2017-09-23 /pmc/articles/PMC5691622/ /pubmed/28946621 http://dx.doi.org/10.3390/v9100270 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leymarie, Olivier Lepont, Leslie Berlioz-Torrent, Clarisse Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title_full | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title_fullStr | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title_full_unstemmed | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title_short | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
title_sort | canonical and non-canonical autophagy in hiv-1 replication cycle |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691622/ https://www.ncbi.nlm.nih.gov/pubmed/28946621 http://dx.doi.org/10.3390/v9100270 |
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