Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophorafl...

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Detalles Bibliográficos
Autores principales: Sze, Alexandre, Olagnier, David, Bel Hadj, Samar, Han, Xiaoying, Hong Tian, Xiao, Xu, Hong-Tao, Yang, Long, Shi, Qingwen, Wang, Penghua, Wainberg, Mark A., Hui Wu, Jian, Lin, Rongtuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691638/
https://www.ncbi.nlm.nih.gov/pubmed/28972551
http://dx.doi.org/10.3390/v9100287
Descripción
Sumario:Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.

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