Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophorafl...

Descripción completa

Detalles Bibliográficos
Autores principales: Sze, Alexandre, Olagnier, David, Bel Hadj, Samar, Han, Xiaoying, Hong Tian, Xiao, Xu, Hong-Tao, Yang, Long, Shi, Qingwen, Wang, Penghua, Wainberg, Mark A., Hui Wu, Jian, Lin, Rongtuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691638/
https://www.ncbi.nlm.nih.gov/pubmed/28972551
http://dx.doi.org/10.3390/v9100287
_version_ 1783279827512459264
author Sze, Alexandre
Olagnier, David
Bel Hadj, Samar
Han, Xiaoying
Hong Tian, Xiao
Xu, Hong-Tao
Yang, Long
Shi, Qingwen
Wang, Penghua
Wainberg, Mark A.
Hui Wu, Jian
Lin, Rongtuan
author_facet Sze, Alexandre
Olagnier, David
Bel Hadj, Samar
Han, Xiaoying
Hong Tian, Xiao
Xu, Hong-Tao
Yang, Long
Shi, Qingwen
Wang, Penghua
Wainberg, Mark A.
Hui Wu, Jian
Lin, Rongtuan
author_sort Sze, Alexandre
collection PubMed
description Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.
format Online
Article
Text
id pubmed-5691638
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-56916382017-11-22 Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference Sze, Alexandre Olagnier, David Bel Hadj, Samar Han, Xiaoying Hong Tian, Xiao Xu, Hong-Tao Yang, Long Shi, Qingwen Wang, Penghua Wainberg, Mark A. Hui Wu, Jian Lin, Rongtuan Viruses Brief Report Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research. MDPI 2017-10-03 /pmc/articles/PMC5691638/ /pubmed/28972551 http://dx.doi.org/10.3390/v9100287 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Sze, Alexandre
Olagnier, David
Bel Hadj, Samar
Han, Xiaoying
Hong Tian, Xiao
Xu, Hong-Tao
Yang, Long
Shi, Qingwen
Wang, Penghua
Wainberg, Mark A.
Hui Wu, Jian
Lin, Rongtuan
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title_full Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title_fullStr Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title_full_unstemmed Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title_short Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
title_sort sophoraflavenone g restricts dengue and zika virus infection via rna polymerase interference
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691638/
https://www.ncbi.nlm.nih.gov/pubmed/28972551
http://dx.doi.org/10.3390/v9100287
work_keys_str_mv AT szealexandre sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT olagnierdavid sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT belhadjsamar sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT hanxiaoying sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT hongtianxiao sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT xuhongtao sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT yanglong sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT shiqingwen sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT wangpenghua sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT wainbergmarka sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT huiwujian sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference
AT linrongtuan sophoraflavenonegrestrictsdengueandzikavirusinfectionviarnapolymeraseinterference

Ejemplares similares