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Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes

There is increasing interest of which dietary patterns can modify the association of fat mass and obesity associated (FTO) variants with obesity. This study was aimed at investigating the interaction of the Mediterranean dietary pattern (Med Diet) with FTO polymorphisms in relation to obesity phenot...

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Autores principales: Hosseini-Esfahani, Firoozeh, Koochakpoor, Gelareh, Daneshpour, Maryam S., Sedaghati-khayat, Bahareh, Mirmiran, Parvin, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691681/
https://www.ncbi.nlm.nih.gov/pubmed/28954439
http://dx.doi.org/10.3390/nu9101064
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author Hosseini-Esfahani, Firoozeh
Koochakpoor, Gelareh
Daneshpour, Maryam S.
Sedaghati-khayat, Bahareh
Mirmiran, Parvin
Azizi, Fereidoun
author_facet Hosseini-Esfahani, Firoozeh
Koochakpoor, Gelareh
Daneshpour, Maryam S.
Sedaghati-khayat, Bahareh
Mirmiran, Parvin
Azizi, Fereidoun
author_sort Hosseini-Esfahani, Firoozeh
collection PubMed
description There is increasing interest of which dietary patterns can modify the association of fat mass and obesity associated (FTO) variants with obesity. This study was aimed at investigating the interaction of the Mediterranean dietary pattern (Med Diet) with FTO polymorphisms in relation to obesity phenotypes. Subjects of this nested case-control study were selected from the Tehran Lipid and Glucose Study participants. Each case was individually matched with a normal weight control (n = 1254). Selected polymorphisms (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973, and rs3751812) were genotyped. Genetic risk score (GRS) were calculated using the weighted method. The Mediterranean dietary score (MDS) was computed. Individuals with minor allele carriers of rs9939973, rs8050136, rs1781749, and rs3751812 had lower risk of obesity when they had higher MDS, compared to wild-type homozygote genotype carriers. The obesity risk was decreased across quartiles of MDS in participants with high GRS (OR: 1, 0.8, 0.79, 0.67) compared to individuals with low GRS (OR: 1.33, 1.06, 0.97, 1.12) (Pinteraction < 0.05). No significant interaction between the GRS and MDS on abdominal obesity was found. A higher Med Diet adherence was associated with lower obesity risk in subjects with more genetic predisposition to obesity, compared to those with lower adherence to the Med Diet and lower GRS.
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spelling pubmed-56916812017-11-22 Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes Hosseini-Esfahani, Firoozeh Koochakpoor, Gelareh Daneshpour, Maryam S. Sedaghati-khayat, Bahareh Mirmiran, Parvin Azizi, Fereidoun Nutrients Article There is increasing interest of which dietary patterns can modify the association of fat mass and obesity associated (FTO) variants with obesity. This study was aimed at investigating the interaction of the Mediterranean dietary pattern (Med Diet) with FTO polymorphisms in relation to obesity phenotypes. Subjects of this nested case-control study were selected from the Tehran Lipid and Glucose Study participants. Each case was individually matched with a normal weight control (n = 1254). Selected polymorphisms (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973, and rs3751812) were genotyped. Genetic risk score (GRS) were calculated using the weighted method. The Mediterranean dietary score (MDS) was computed. Individuals with minor allele carriers of rs9939973, rs8050136, rs1781749, and rs3751812 had lower risk of obesity when they had higher MDS, compared to wild-type homozygote genotype carriers. The obesity risk was decreased across quartiles of MDS in participants with high GRS (OR: 1, 0.8, 0.79, 0.67) compared to individuals with low GRS (OR: 1.33, 1.06, 0.97, 1.12) (Pinteraction < 0.05). No significant interaction between the GRS and MDS on abdominal obesity was found. A higher Med Diet adherence was associated with lower obesity risk in subjects with more genetic predisposition to obesity, compared to those with lower adherence to the Med Diet and lower GRS. MDPI 2017-09-26 /pmc/articles/PMC5691681/ /pubmed/28954439 http://dx.doi.org/10.3390/nu9101064 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hosseini-Esfahani, Firoozeh
Koochakpoor, Gelareh
Daneshpour, Maryam S.
Sedaghati-khayat, Bahareh
Mirmiran, Parvin
Azizi, Fereidoun
Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title_full Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title_fullStr Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title_full_unstemmed Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title_short Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
title_sort mediterranean dietary pattern adherence modify the association between fto genetic variations and obesity phenotypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691681/
https://www.ncbi.nlm.nih.gov/pubmed/28954439
http://dx.doi.org/10.3390/nu9101064
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