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Vitamin D and Age-Related Macular Degeneration

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active meta...

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Detalles Bibliográficos
Autores principales: Garcia Layana, Alfredo, Minnella, Angelo Maria, Garhöfer, Gerhard, Aslam, Tariq, Holz, Frank G., Leys, Anita, Silva, Rufino, Delcourt, Cécile, Souied, Eric, Seddon, Johanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691736/
https://www.ncbi.nlm.nih.gov/pubmed/29027953
http://dx.doi.org/10.3390/nu9101120
Descripción
Sumario:In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.