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L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels

BACKGROUND: To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model. METHODS: The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administered once...

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Detalles Bibliográficos
Autores principales:	Chen, Liang, Wu, Xianglei, Zhong, Jun, Li, Dongqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691865/ https://www.ncbi.nlm.nih.gov/pubmed/29145862 http://dx.doi.org/10.1186/s12891-017-1819-3

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