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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia

Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their pathobiological roles in tumors is still very limited. We report here that the GEF Vav...

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Detalles Bibliográficos
Autores principales:	Robles-Valero, Javier, Lorenzo-Martín, L. Francisco, Menacho-Márquez, Mauricio, Fernández-Pisonero, Isabel, Abad, Antonio, Camós, Mireia, Toribio, María L., Espinosa, Lluis, Bigas, Anna, Bustelo, Xosé R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691892/ https://www.ncbi.nlm.nih.gov/pubmed/29136506 http://dx.doi.org/10.1016/j.ccell.2017.10.004

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