Cargando…

Placement of Hydroxy Moiety on Pendant of Peptidomimetic Scaffold Modulates Mu and Kappa Opioid Receptor Efficacy

[Image: see text] In an effort to expand the structure–activity relationship (SAR) studies of a series of mixed-efficacy opioid ligands, peptidomimetics that incorporate methoxy and hydroxy groups around a benzyl or 2-methylindanyl pendant on a tetrahydroquinoline (THQ) core of the peptidomimetics w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harland, Aubrie A., Pogozheva, Irina D., Griggs, Nicholas W., Trask, Tyler J., Traynor, John R., Mosberg, Henry I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691919/ https://www.ncbi.nlm.nih.gov/pubmed/28796483 http://dx.doi.org/10.1021/acschemneuro.7b00284

Ejemplares similares

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands
por: Harland, Aubrie A., et al.
Publicado: (2016)

Structure–Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics
por: Montgomery, Deanna, et al.
Publicado: (2019)

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity
por: Greedy, Benjamin M., et al.
Publicado: (2013)

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
por: Kumar, Vinod, et al.
Publicado: (2014)

Differential Stability of the Crystallographic Interfaces of Mu- and Kappa-Opioid Receptors
por: Johnston, Jennifer M., et al.
Publicado: (2014)

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits
por: Kim, Brian S., et al.
Publicado: (2022)

Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
por: Neubert, John K, et al.
Publicado: (2007)

Kappa but not delta or mu opioid receptors form homodimers at low membrane densities
por: Cechova, Kristina, et al.
Publicado: (2021)

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
por: Lee, Yeon Sun
Publicado: (2022)

Dynamic lateral organization of opioid receptors (kappa, mu(wt) and mu(N40D)) in the plasma membrane at the nanoscale level
por: Rogacki, Maciej K., et al.
Publicado: (2018)

Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors
por: Zaveri, Nurulain T., et al.
Publicado: (2015)

Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment
por: CHATTI, Imen, et al.
Publicado: (2017)

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors
por: Cueva, Juan Pablo, et al.
Publicado: (2015)

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy
por: Olson, Keith M., et al.
Publicado: (2023)

Random Copolymers of Styrene with Pendant Fluorophore Moieties: Synthesis and Applications as Fluorescence Sensors for Nitroaromatics
por: Zen Eddin, Mohamad, et al.
Publicado: (2022)

Neurons derived from human-induced pluripotent stem cells express mu and kappa opioid receptors
por: Ju, Zhi-Hai, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
por: Zhu, Mengwei, et al.
Publicado: (2023)

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
por: Abdildinova, Aizhan, et al.
Publicado: (2021)

Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships
por: Journigan, V. Blair, et al.
Publicado: (2017)

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold
por: Reed, Brian, et al.
Publicado: (2022)

Varying Expression of Mu and Kappa Opioid Receptors in Cockatiels (Nymphicus hollandicus) and Domestic Pigeons (Columba livia domestica)
por: Fousse, Samantha L., et al.
Publicado: (2020)

Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications
por: Elmariah, Sarina, et al.
Publicado: (2022)

The role of hydrophobic interactions in positioning of peripheral proteins in membranes
por: Lomize, Andrei L, et al.
Publicado: (2007)

Unprecedented Biodegradable Cellulose-Derived Polyesters with Pendant Citronellol Moieties: From Monomer Synthesis to Enzymatic Degradation
por: Kayishaer, Aihemaiti, et al.
Publicado: (2021)

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA(A) Receptor
por: Li, Guanguan, et al.
Publicado: (2020)

Pharmacological profiles of opioid ligands at Kappa opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2006)

Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, δ Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute Tolerance
por: Mosberg, Henry I., et al.
Publicado: (2014)

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor
por: Livingston, Kathryn E, et al.
Publicado: (2018)

Therapeutic Potential of Kappa Opioid Agonists
por: Beck, Tyler C., et al.
Publicado: (2019)

Peptidomimetics II
por: Lubell, William D
Publicado: (2016)

OPM database and PPM web server: resources for positioning of proteins in membranes
por: Lomize, Mikhail A., et al.
Publicado: (2012)

Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies
Publicado: (1986)

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators
por: Olson, Keith M., et al.
Publicado: (2021)

Peptidomimetics Based On Dehydroepiandrosterone Scaffold: Synthesis, Antiproliferation Activity, Structure-Activity Relationship, and Mechanisms
por: Wang, Xiaohui, et al.
Publicado: (2016)

DeepCubist: Molecular Generator for Designing Peptidomimetics based on Complex three-dimensional scaffolds
por: Umedera, Kohei, et al.
Publicado: (2022)

Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?
por: Peckham, Alyssa M., et al.
Publicado: (2018)

Peptidomimetics in cancer targeting
por: Gomari, Mohammad Mahmoudi, et al.
Publicado: (2022)

Synthesis, Pharmacological Evaluation, and Computational Studies of Cyclic Opioid Peptidomimetics Containing β(3)-Lysine
por: Wtorek, Karol, et al.
Publicado: (2021)

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
por: Isidro-Llobet, Albert, et al.
Publicado: (2015)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
por: Murányi, Marianna, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_954q4a0kkhqdb4rr88am18c6q6